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- Table of Contents
NDFIP2 Antibodies
AND NDFIP2 ELISA kits, NDFIP2 Proteins
Many biological assays use antibodies to detect NDFIP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NDFIP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NDFIP2 antibodies...
Designing an IHC experiment for NDFIP2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the NDFIP2 IHC GuideNDFIP2 Infographic by Boster Bio
All NDFIP2 Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M08384
100 μg/vial
Cat # M08384
100 μg/vial
NDFIP2 Overview
Facts about NEDD4 family-interacting protein 2.
NEDD4 family-interacting protein 2 (NDFIP2)
Activates HECT domain-containing E3 ubiquitin-protein ligases, such as ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of the targets. Consequently, may control many cellular processes.
Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with station maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (PubMed:26363003).
Gene Information
| Human | |
|---|---|
| Gene Name: | NDFIP2 |
| Uniprot: | Q9NV92 |
| Entrez: | 54602 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
FLJ25842; KIAA1165N4WBP5APutative MAPK-activating protein PM04/PM05/PM06/PM07; MAPK-activating protein PM04 PM05 PM06 PM07; N4wbp5a; Nedd4 family interacting protein 2; NEDD4 family-interacting protein 2; NEDD4 WW domain-binding protein 5A; NF-kappa-B-activating protein 413; Putative NF-kappa-B-activating protein 413
Molecular Weight
Mass (kDA):
36.39 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q31.1 |
| Sequence: | 13; NC_000013.11 (79480722..79556077) |
Tissue Specificity
Expressed in brain, lung, heart, skeletal muscle, kidney, liver and placenta.
Subcellular Localizations
Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane. Endosome, multivesicular body membrane.
Diseases
- Atresia
- Anemia
- Hypochromic Anemia
- Iron Overload
- Diabetes Mellitus
- Immunologic Deficiency Syndromes
- Iron Deficiency Anemia
- Inflammatory Disorder
- Hypertensive Disease
- Renal Hypertension
Pathways
- Transport
- Pathogenesis
- Receptor-mediated Endocytosis
- Cell Activation
- Vesicle Transport
- T Cell Activation
- Endocytosis
- Neuron Development
- Ovulation
- Sexual Reproduction
PTMs
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NDFIP2
bosterbio.com/bosterbio-gene-info-cards/NDFIP2
References
PMID: 12796489 by Cristillo A.D., et al. Cloning and characterization of N4WBP5A, an inducible, cyclosporine- sensitive, Nedd4-binding protein in human T lymphocytes.
PMID: 12761501 by Matsuda A., et al. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.