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- Table of Contents
NDUFS1 Antibodies
AND NDUFS1 ELISA kits, NDUFS1 Proteins
Many biological assays use antibodies to detect NDUFS1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NDUFS1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NDUFS1 antibodies...
Designing a Western blot for NDUFS1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the NDUFS1 Western Blot GuideDesigning an IHC experiment for NDUFS1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the NDUFS1 IHC GuideNDUFS1 Infographic by Boster Bio
All NDUFS1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A04920-1
100 μg/vial
Cat # A04920-1
100 μg/vial
NDUFS1 Overview
Facts about NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial.
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (NDUFS1)
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is thought to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain.
The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a part of the iron-sulfur (IP) fragment of the enzyme.
Gene Information
| Human | |
|---|---|
| Gene Name: | NDUFS1 |
| Uniprot: | P28331 |
| Entrez: | 4719 |
Family
| Belongs to: |
|---|
| complex I 75 kDa subunit family |
Alternative Names
CI-75k; CI-75Kd; complex I 75kDa subunit; complex I, mitochondrial respiratory chain, 75-kD subunit; Complex I-75kD; EC 1.6.5.3; EC 1.6.99.3; MGC26839; mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit; NADH dehydrogenase (ubiquinone) Fe-S protein 1 (75kD) (NADH-coenzyme Qreductase); NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Qreductase); NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; PRO1304
Molecular Weight
Mass (kDA):
79.468 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q33.3 |
| Sequence: | 2; NC_000002.12 (206114817..206159444, complement) |
Subcellular Localizations
Mitochondrion inner membrane.
Diseases
- Nicotinamide Adenine Dinucleotide Coenzyme Q Reductase Deficiency
- Mitochondrial Diseases
- Leigh Disease
- Parkinson Disease
- Mitochondrial Encephalomyopathies
- Leukoencephalopathies
- Nervous System Disorder
- Malignant Neoplasms
- Acidosis
- Hereditary Diseases
- Acidosis, Lactic
- Neuroblastoma
Pathways
- Oxidative Phosphorylation
- Pathogenesis
- Transport
- Electron Transport
- Electron Transport Chain
- Localization
- Aging
- Mitochondrial Outer Membrane Permeabilization
- Fertilization
- Dna Repair
- Swimming
- Translation
PTMs
- Phosphorylation
- Deacetylation
Research Areas
- Vision
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NDUFS1
bosterbio.com/bosterbio-gene-info-cards/NDUFS1
References
PMID: 1935949 by Chow W., et al. Determination of the cDNA sequence for the human mitochondrial 75-kDa Fe-S protein of NADH-coenzyme Q reductase.
PMID: 11349233 by Benit P., et al. Large-scale deletion and point mutations of the nuclear NDUFV1 and NDUFS1 genes in mitochondrial complex I deficiency.