This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Nectin-2 Antibodies
AND NECTIN2 ELISA kits, Nectin-2 Proteins
Many biological assays use antibodies to detect Nectin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Nectin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Nectin-2 antibodies...
Designing a Western blot for Nectin-2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the NECTIN2 Western Blot GuideDesigning an IHC experiment for Nectin-2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the NECTIN2 IHC GuideNECTIN2 Infographic by Boster Bio
All NECTIN2 Products
Product
Figures
Specificity
Applications
Price
Human, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A08081-2
100 μg/vial
Cat # A08081-2
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # M08081-2
100 μl/vial
Cat # M08081-2
100 μl/vial
Human
ELISA
$499
Cat # EK1960
96 wells/kit, with removable strips.
Cat # EK1960
96 wells/kit, with removable strips.
NECTIN2 Overview
Facts about Nectin-2.
Nectin-2 (NECTIN2)
Modulator of T-cell signaling.
Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to.Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation.
Gene Information
| Human | |
|---|---|
| Gene Name: | NECTIN2 |
| Uniprot: | Q92692 |
| Entrez: | 5819 |
Family
| Belongs to: |
|---|
| nectin family |
Alternative Names
CD112 antigen; CD112; Herpes virus entry mediator B; Herpesvirus entry mediator B; herpesvirus entry protein B; HVEB; HVEBpoliovirus receptor-like 2; MPH; nectin 2; Nectin2; Nectin-2; poliovirus receptor-related 2 (herpesvirus entry mediator B); poliovirus receptor-related protein 2; PRR2; PRR2nectin-2; PVRL2; PVRR2poliovirus receptor related 2
Molecular Weight
Mass (kDA):
57.742 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.32 |
| Sequence: | 19; NC_000019.10 (44846297..44889223) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein.
Diseases
- Congenital Abnormality
- Cleft Lip
- Cleft Palate
- Tissue Adhesions
- Malignant Neoplasms
- Neoplasms
- Dysequilibrium Syndrome
- Alzheimer's Disease
- Sclerosis
- Hepatitis B
- Carcinoma
- Lymphoma
- Cytogenetic Abnormality
Interacting Proteins
- AFDN
- CD226
- DNAJC5
- KRTAP10-5
- KRTAP10-7
- KRTAP5-9
- MDFI
- NECTIN3
- NOTCH2NL
- SIAH1
Pathways
- Pathogenesis
- Cell Adhesion
- Transport
- Intracellular Transport
- Cell Proliferation
- Cell-cell Signaling
- Aging
- Cell Differentiation
- Cellular Process
PTMs
- Disulfide bond
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NECTIN2
bosterbio.com/bosterbio-gene-info-cards/NECTIN2
References
PMID: 7622062 by Eberle F., et al. The human PRR2 gene, related to the human poliovirus receptor gene (PVR), is the true homolog of the murine MPH gene.
PMID: 9657005 by Warner M.S., et al. A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus.