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- Table of Contents
NFATC3 Antibodies
AND NFATC3 ELISA kits, NFATC3 Proteins
Many biological assays use antibodies to detect NFATC3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NFATC3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NFATC3 antibodies...
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NFATC3 Infographic by Boster Bio
All NFATC3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, ICC, WB
$370
Cat # A02727-2
100 μg/vial
Cat # A02727-2
100 μg/vial
Human, Mouse
ELISA
$480
Cat # EKC1399
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1399
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse
ELISA
$540
Cat # EKC2092
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2092
1 kit, containing two 96-well plates and all necessary reagents
NFATC3 Overview
Facts about Nuclear factor of activated T-cells, cytoplasmic 3.
Nuclear factor of activated T-cells, cytoplasmic 3 (NFATC3)
Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, particularly in the induction of the IL-2.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | NFATC3 |
| Uniprot: | Q12968 |
| Entrez: | 4775 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
NFAT4; NF-AT4; NFAT4nuclear factor of activated T-cells, cytoplasmic 3; NFATC3; NF-ATc3; NFATX; nuclear factor of activated T-cells c3 isoform IE-Xa; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3; T cell transcription factor NFAT4; T-cell transcription factor NFAT4
Molecular Weight
Mass (kDA):
115.594 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16q22.1 |
| Sequence: | 16; NC_000016.10 (68085370..68229259) |
Tissue Specificity
Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle.
Subcellular Localizations
Cytoplasm. Nucleus. Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
Diseases
- Hypertrophy
- Cardiac Hypertrophy
- Neoplasms
- Hypertensive Disease
- Heart Failure
- Hypoxia
- Malignant Neoplasms
- Anoxia
- Tumor Angiogenesis
- Carcinoma
- Fibrosis
- Pulmonary Hypertension
- Leukemia
Interacting Proteins
- RAF1
Pathways
- Localization
- Nuclear Export
- Cell Differentiation
- Immune Response
- Nuclear Import
- Cell Proliferation
- Cell Development
- Angiogenesis
- Cell Activation
- Surfactant Homeostasis
- Heart Development
- Membrane Depolarization
- Translation
PTMs
- Dephosphorylation
- Phosphorylation
- Reduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NFATC3
bosterbio.com/bosterbio-gene-info-cards/NFATC3
References
PMID: 7749981 by Hoey T., et al. Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins.
PMID: 7739550 by Masuda E.S., et al. NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus.