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- Table of Contents
NFKBIA Antibodies
AND NFKBIA ELISA kits, NFKBIA Proteins
Many biological assays use antibodies to detect NFKBIA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NFKBIA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NFKBIA antibodies...
Designing a Western blot for NFKBIA? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the NFKBIA Western Blot GuideDesigning an IHC experiment for NFKBIA? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the NFKBIA IHC GuideNFKBIA Infographic by Boster Bio
All NFKBIA Products
Product
Figures
Specificity
Applications
Price
Anti-IKB alpha NFKBIA Rabbit Monoclonal Antibody
10 Citations
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M01139
100 μl
Cat # M01139
100 μl
Human, Mouse
Flow Cytometry, WB
$370
Cat # P01139-1
100 μl/vial
Cat # P01139-1
100 μl/vial
Human
IP, WB
$370
Cat # P01139
100 μl
Cat # P01139
100 μl
Human, Mouse, Rat
ELISA
$540
Cat # EKC2439
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2439
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2295
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2295
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1311
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1311
1 kit, containing one 96-well plate and all necessary reagents
NFKBIA Overview
Facts about NF-kappa-B inhibitor alpha.
NF-kappa-B inhibitor alpha (NFKBIA)
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers from the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by resistant and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate into the nucleus and activate transcription.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | NFKBIA |
| Uniprot: | P25963 |
| Entrez: | 4792 |
Family
| Belongs to: |
|---|
| NF-kappa-B inhibitor family |
Alternative Names
alpha; I-kappa-B-alpha; IkappaBalphaNF-kappa-B inhibitor alpha; IKBAikB-alpha; IkBalpha; IkB-alpha; MAD3; MAD-3; Major histocompatibility complex enhancer-binding protein MAD3; NFKBI; NFKBIA; nuclear factor of kappa light chain gene enhancer in B-cells; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor
Molecular Weight
Mass (kDA):
35.609 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q13.2 |
| Sequence: | 14; NC_000014.9 (35401513..35404749, complement) |
Subcellular Localizations
Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.
Diseases
- Neoplasms
- Malignant Neoplasms
- Inflammation
- Inflammatory Response
- Lymphoma
- Malignant Paraganglionic Neoplasm
- Hodgkin Disease
- Carcinoma
- Tissue Adhesions
- Innate Immune Response
- Neoplasm Metastasis
- Autoimmune Diseases
- Crohn Disease
Interacting Proteins
- CHUK
- COMMD1
- CTNNA1
- FBXW11
- GRK2
- GRK5
- HIF1AN
- IKBKB
- IKBKG
- NEDD9
Pathways
- Immune Response
- Inflammatory Response
- Pathogenesis
- Cell Proliferation
- Translation
- Innate Immune Response
- Cell Death
- Cell Cycle
- Cytokine Production
- Localization
- Methylation
- Rna Interference
- Secretion
PTMs
- Phosphorylation
- Biotinylation
Research Areas
- Apoptosis
- Chaperone-Mediated Autophagy (CMA)
- Diabetes Research
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NFKBIA
bosterbio.com/bosterbio-gene-info-cards/NFKBIA
References
PMID: 1829648 by Haskill S., et al. Characterization of an immediate-early gene induced in adherent monocytes that encodes I kappa B-like activity.
PMID: 10637284 by Jungnickel B., et al. Clonal deleterious mutations in the IkappaB alpha gene in the malignant cells in Hodgkin's lymphoma.
20 Publications of Boster NFKBIA Antibodies & ELISA Kits
- PubMed ID: 10.4314/tjpr.v16i11.13, Prophylactic effects of triptolide on colon cancer development in azoxymethane/d...
- PubMed ID: 10.3389/fphys.2021.707344, Pioglitazone Ameliorates Renal Ischemia-Reperfusion Injury via Inhibition of NF-...
- PubMed ID: 10.3109/13880209.2014.898075, Effect of ammonium pyrrolidine dithiocarbamate (PDTC) on NF-κB activation and C...
- PubMed ID: 10.1620/tjem.222.7, Growth Hormone Releasing Peptide-2, a Ghrelin Agonist, Attenuates Lipopolysaccha...
- PubMed ID: 10.1111/j.1745-7270.2006.00136.x, Regulatory Peptides Modulate Adhesion of Polymorphonuclear Leukocytes to Bronchi...
- PubMed ID: 10.1111/febs.13767@10.1111, Low doses of paclitaxel enhance liver metastasis of breast cancer cells in the m...
- PubMed ID: 10.1111/febs.13767, Low doses of paclitaxel enhance liver metastasis of breast cancer cells in the m...
- PubMed ID: 10.1016/j.jtemb.2011.04.001, The effect of DHEA treatment on the oxidative stress and myocardial fibrosis ind...
- PubMed ID: 10.1016/j.jff.2015.08.032, Ameliorative effectiveness of allicin on acetaminophen-induced acute liver damag...
- PubMed ID: 10.1016/j.intimp.2021.108119, Nootkatone protects cartilage against degeneration in mice by inhibiting NF-κB ...
- PubMed ID: 10.1016/j.clim.2021.108914, Epigenetic regulation is involved in traffic-related PM2.5 aggravating allergic ...
- PubMed ID: 10.1007/s10753-010-9197-0, Norisoboldine Inhibits the Production of Pro-inflammatory Cytokines in Lipopolys...
- PubMed ID: -, Huanyue Cui,Xueying Liu,Jin Zhang,Ke Zhang,Dahong Yao,Shi Dong,Shushu Feng,Lu Ya...
- PubMed ID: 24889421, N-acetylcysteine reduces oxidative stress, nuclear factor-?B activity and cardio...
- PubMed ID: 26046540, Downregulation of TNIP1 Expression Leads to Increased Proliferation of Human Ker...
- PubMed ID: 20208988, Multi-gene targeted antiangiogenic therapies for experimental corneal neovascula...
- PubMed ID: 27350130, Rumen-derived lipopolysaccharide enhances the expression of lingual antimicrobia...
- PubMed ID: 28694207, Liao, Z., Wang, J., Tan, H., & Wei, L. (2017). Cinnamon extracts exert intrapanc...
- PubMed ID: 20193848, Liu X, Yu H, Yang W, Zhou X, Lu H, Shi D. Cancer Genet Cytogenet. 2010 Mar;197(2...
- PubMed ID: 25820389, Xu T, Ni Mm, Huang C, Meng Xm, He Yh, Zhang L, Li J. Inflammation. 2015 Oct;38(5...
*More publications can be found for each product on its corresponding product page