NLR family CARD domain-containing protein 3 (NLRC3)

Negative regulator of the innate immune response (PubMed:15705585, PubMed:22863753, PubMed:25277106). Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in reaction to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus disease, such as that of Herpes simplex virus 1 (HSV1) (By similarity) (PubMed:22863753).

May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, diminishing the activating'Lys-63'- linked ubiquitination and leaving off the degradative'Lys- 48'-linked ubiquitination (PubMed:22863753). Inhibits the PI3K- AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and diminishing PIK3R1/PIK3R2 activation.