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- Table of Contents
NLRP12 Antibodies
AND NLRP12 ELISA kits, NLRP12 Proteins
Many biological assays use antibodies to detect NLRP12, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NLRP12 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NLRP12 antibodies...
Designing a Western blot for NLRP12? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the NLRP12 Western Blot GuideDesigning an IHC experiment for NLRP12? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the NLRP12 IHC GuideNLRP12 Infographic by Boster Bio
All NLRP12 Products
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NLRP12 Overview
Facts about NACHT, LRR and PYD domains-containing protein 12.
NACHT, LRR and PYD domains-containing protein 12 (NLRP12)
May mediate activation of CASP1 Through ASC and promote activation of NF-kappa-B Through IKK.
.Gene Information
| Human | |
|---|---|
| Gene Name: | NLRP12 |
| Uniprot: | P59046 |
| Entrez: | 91662 |
Family
| Belongs to: |
|---|
| NLRP family |
Alternative Names
FCAS2; Monarch-1; NACHT, leucine rich repeat and PYD containing 12; NACHT, LRR and PYD domains-containing protein 12; NALP12LRR and PYD containing protein 12; NLR family, pyrin domain containing 12; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 12; PYPAF7Monarch1; PYRIN-containing APAF1-like protein 7; Regulated by nitric oxide; RNO2
Molecular Weight
Mass (kDA):
120.173 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.42 |
| Sequence: | 19; NC_000019.10 (53793584..53824403, complement) |
Tissue Specificity
Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.
Subcellular Localizations
Cytoplasm.
Diseases
- Inflammation
- Hereditary Autoinflammatory Diseases
- Familial Mediterranean Fever
- Neoplasms
- Autoimmune Diseases
- Inflammatory Response
- Cell Transformation, Neoplastic
- Malignant Neoplasms
- Hereditary Diseases
- Dermatitis, Atopic
- Contact Hypersensitivity
- Colitis
Pathways
- Pathogenesis
- Secretion
- Inflammatory Response
- Immune Response
- Hypersensitivity
- Hyperphosphorylation
- Cell Activation
- Cell Proliferation
- Cell Migration
- Proteolysis
PTMs
- Phosphorylation
Research Areas
- Apoptosis
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NLRP12
bosterbio.com/bosterbio-gene-info-cards/NLRP12
References
PMID: 12019269 by Wang L., et al. PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing.
PMID: 12563287 by Tschopp J., et al. NALPs: a novel protein family involved in inflammation.