NLR family member X1 Antibodies

AND NLRX1 ELISA kits, NLR family member X1 Proteins

Many biological assays use antibodies to detect NLR family member X1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NLR family member X1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NLR family member X1 antibodies...

We validate the specificity of these antibodies to NLR family member X1 by testing them on tissues known to express NLRX1 positively and negatively. Browse below to find the NLRX1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for NLR family member X1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the NLRX1 IHC Guide

NLRX1 Infographic by Boster Bio

All NLRX1 Products

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Anti-NLRX1 Antibody Picoband®

Western blot analysis of NLRX1 using anti-NLRX1 antibody (A04980-3)

IHC analysis of NLRX1 using anti-NLRX1 antibody (A04980-3)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A04980-3
100 µg/vial

NLRX1 (NM_024618) Human Over-expression Lysate

Human

$628
Cat # LS079671
20 µg, 100 µg

NLRX1 Overview

Facts about NLR family member X1.

NLRX1 3D structure. Source: alphafold

NLR family member X1 (NLRX1)

Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of this virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010).

Instead, promotes autophagy by interacting with TUFM and then recruiting the autophagy- related proteins ATG5 and ATG12 (PubMed:22749352). Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910).

Gene Information

Human
Gene Name:	NLRX1
Uniprot:	Q86UT6
Entrez:	79671

Family

Belongs to:

NLRP family

Alternative Names

Caterpiller protein 11.3; CLR11.3DLNB26; MGC131937; MGC21025; NLR family member X1; NLR family, X1; NOD26; NOD5; NOD9FLJ21478; NOD-like receptor X1; Nucleotide-binding oligomerization domain protein 26; Nucleotide-binding oligomerization domain protein 5; Nucleotide-binding oligomerization domain protein 9; nucleotide-binding oligomerization domain, leucine rich repeat containing X1

Molecular Weight

Mass (kDA):
107.616 kDA

Genomic Context


Human

Location:	11q23.3
Sequence:	11; NC_000011.10 (119168334..119184016)

Tissue Specificity

Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL-60, Raji and Jurkat cell lines (at protein level).

Subcellular Localizations

Mitochondrion outer membrane.

Diseases

Virus Diseases
Inflammation
Innate Immune Response
Vesicular Stomatitis
Shigella Infections
Sting Injury
Stomatitis
Acquired Immunodeficiency Syndrome
Simian Acquired Immunodeficiency Syndrome
Melanoma
Infertility
Orthomyxoviridae Infections

Septic Shock
Hemorrhage
Disease Caused By Shigella Flexneri
Chlamydia Infections
Bacterial Infections
Chronic Arthritis
Rna Virus Infections

Interacting Proteins

Sarm1
TUFM

Pathways

Cell Death
Programmed Cell Death
Innate Immune Response
Immune Response
Viral Replication
Type I Interferon Production
Translation
Oxidative Phosphorylation

Pathogenesis
Autophagy

PTMs

Phosphorylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NLRX1

References

PMID: 12766759 by Inohara N., et al. NODs: intracellular proteins involved in inflammation and apoptosis.

PMID: 15952891 by Inohara N., et al. NOD-LRR proteins: role in host-microbial interactions and inflammatory disease.