NOTCH2 Antibodies

AND NOTCH2 ELISA kits, NOTCH2 Proteins

Many biological assays use antibodies to detect NOTCH2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NOTCH2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NOTCH2 antibodies...

We validate the specificity of these antibodies to NOTCH2 by testing them on tissues known to express NOTCH2 positively and negatively. Browse below to find the NOTCH2 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NOTCH2 Infographic by Boster Bio

All NOTCH2 Products

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Specificity

Applications

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Anti-NOTCH 2 Antibody

1 Q&As

Human

ELISA, IHC, WB

$641
Cat # A00518
200uL

Anti-NOTCH2 Antibody Picoband®

Western blot analysis of NOTCH2 using anti-NOTCH2 antibody (A00518-2)

IHC analysis of NOTCH2 using anti-NOTCH2 antibody (A00518-2)

Human, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A00518-2
100 μg/vial

Anti-Notch 2 Antibody

Western blot analysis of NOTCH2 expression in HEK293T (A), HepG2 (B), H1792 (C), H9C2 (D), AML12 (E) whole cell lysates

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A00518-1
100ul

Anti-Cleaved-Notch 2 (D1733) Antibody

Western Blot analysis of 293 cells using Cleaved-Notch 2 (D1733) Polyclonal Antibody diluted at 1:500

Immunohistochemical analysis of paraffin-embedded Rat-lung tissue

Western Blot analysis of various cells using Cleaved-Notch 2 (D1733) Polyclonal Antibody diluted at 1:500

Human, Mouse, Rat

ELISA, IF, IHC, WB

$380
Cat # A00518-3
100ul

Anti-Notch2 Rabbit Monoclonal Antibody

Human liver was stained with anti-Notch2 rabbit antibody

Human testis was stained with anti-Notch2 rabbit antibody

Mouse liver was stained with anti-Notch2 rabbit antibody

Human, Mouse, Rat

ELISA, IP, IF, IHC, WB

$146
Cat # M00518-1
20μL, 40μL, 100μL, 200μL

NOTCH2 Overview

Facts about Neurogenic locus notch homolog protein 2.

NOTCH2 3D structure. Source: alphafold

Neurogenic locus notch homolog protein 2 (NOTCH2)

Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to modulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989).

Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis.

Gene Information

Human
Gene Name:	NOTCH2
Uniprot:	Q04721
Entrez:	4853

Family

Belongs to:

NOTCH family

Alternative Names

AGS2; hN2; neurogenic locus notch homolog protein 2; Notch (Drosophila) homolog 2; notch 2Notch homolog 2 (Drosophila); Notch homolog 2; Notch2; Notch-2

Molecular Weight

Mass (kDA):
265.405 kDA

Genomic Context


Human

Location:	1p12
Sequence:	1; NC_000001.11 (119911553..120069703, complement)

Tissue Specificity

Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo.

Subcellular Localizations

[Notch 2 extracellular truncation]: Cell membrane; Single-pass type I membrane protein.; [Notch 2 intracellular domain]: Nucleus. Cytoplasm. Following proteolytical processing NICD is translocated to the nucleus. Retained at the cytoplasm by TCIM (PubMed:25985737).