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- Table of Contents
NOTCH2 Antibodies
AND NOTCH2 ELISA kits, NOTCH2 Proteins
Many biological assays use antibodies to detect NOTCH2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NOTCH2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NOTCH2 antibodies...
Designing a Western blot for NOTCH2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the NOTCH2 Western Blot GuideNOTCH2 Infographic by Boster Bio
All NOTCH2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A00518-2
100 μg/vial
Cat # A00518-2
100 μg/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00518-1
20μL, 40μL, 100μL, 200μL
Cat # M00518-1
20μL, 40μL, 100μL, 200μL
NOTCH2 Overview
Facts about Neurogenic locus notch homolog protein 2.
Neurogenic locus notch homolog protein 2 (NOTCH2)
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to modulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989).
Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis.
Gene Information
| Human | |
|---|---|
| Gene Name: | NOTCH2 |
| Uniprot: | Q04721 |
| Entrez: | 4853 |
Family
| Belongs to: |
|---|
| NOTCH family |
Alternative Names
AGS2; hN2; neurogenic locus notch homolog protein 2; Notch (Drosophila) homolog 2; notch 2Notch homolog 2 (Drosophila); Notch homolog 2; Notch2; Notch-2
Molecular Weight
Mass (kDA):
265.405 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p12 |
| Sequence: | 1; NC_000001.11 (119911553..120069703, complement) |
Tissue Specificity
Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo.
Subcellular Localizations
[Notch 2 extracellular truncation]: Cell membrane; Single-pass type I membrane protein.; [Notch 2 intracellular domain]: Nucleus. Cytoplasm. Following proteolytical processing NICD is translocated to the nucleus. Retained at the cytoplasm by TCIM (PubMed:25985737).
Diseases
- Neoplasms
- Malignant Neoplasms
- Cell Transformation, Neoplastic
- Leukemia
- Alagille Syndrome
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Lymphoma
- Brain Neoplasms
- Hyperplasia
- Malignant Neoplasm Of Breast
Pathways
- Notch Signaling Pathway
- Cell Differentiation
- Cell Proliferation
- Pathogenesis
- Cell Cycle
- Cell Development
- Cell Fate Determination
- Localization
- Regeneration
- Neurogenesis
- Cell Growth
- Cell Fate Specification
- Cell Death
PTMs
- Cleavage
- Phosphorylation
- Hydroxylation
Research Areas
- Apoptosis
- Cancer
- Golgi Apparatus Markers
- Growth and Development
- Neuronal Cell Markers
- Signal Transduction
- Stem Cell Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NOTCH2
bosterbio.com/bosterbio-gene-info-cards/NOTCH2
References
PMID: 1303260 by Stifani S., et al. Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins.
PMID: 9244302 by Blaumueller C.M., et al. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane.