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- Table of Contents
Bile acid receptor Antibodies
AND NR1H4 ELISA kits, Bile acid receptor Proteins
Many biological assays use antibodies to detect Bile acid receptor, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Bile acid receptor in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Bile acid receptor antibodies...
Designing a Western blot for Bile acid receptor? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the NR1H4 Western Blot GuideNR1H4 Infographic by Boster Bio
All NR1H4 Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, ICC, WB
$370
Cat # A00835-1
100 μg/vial
Cat # A00835-1
100 μg/vial
Human
$960
Cat # LS009971
20 µg, 100 µg
Cat # LS009971
20 µg, 100 µg
NR1H4 Overview
Facts about Bile acid receptor.
Bile acid receptor (NR1H4)
Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA).
Plays a essential part in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'- AGGTCA-3' where the monomers are spaced by 1 nucleotide (IR-1) but also to intelligently replicate DR1 websites with lower affinity, and may be activated by FXR or RXR-specific ligands.
Gene Information
| Human | |
|---|---|
| Gene Name: | NR1H4 |
| Uniprot: | Q96RI1 |
| Entrez: | 9971 |
Family
| Belongs to: |
|---|
| nuclear hormone receptor family |
Alternative Names
BAR; bile acid receptor; farnesoid X receptor; Farnesoid X-activated receptor; Farnesol receptor HRR-1; FXR; FXRBAR; HRR-1; HRR1MGC163445; NR1H4; Nuclear receptor subfamily 1 group H member 4; nuclear receptor subfamily 1, group H, member 4; Retinoid X receptor-interacting protein 14; RIP14; RIP14RXR-interacting protein 14
Molecular Weight
Mass (kDA):
55.914 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q23.1 |
| Sequence: | 12; NC_000012.12 (100473866..100564414) |
Tissue Specificity
Liver and hepatocyte-related cells express mainly FXRalpha1-type isoforms with isoform 3 and isoform 4 in approximately equal proportions. In intestine and kidney mainly FXRalpha2-type isoforms are expressed with isoform 1 and isoform 2 in approximately equal proportions. Expressed in pancreatic beta cells and macrophages.
Subcellular Localizations
Nucleus.; [Isoform 1]: Nucleus.; [Isoform 2]: Nucleus.; [Isoform 3]: Nucleus.; [Isoform 4]: Nucleus.
Diseases
- Inflammation
- Obesity
- Liver Carcinoma
- Cholestasis
- Liver Diseases
- Insulin Resistance
- Cholecystolithiasis
- Carcinoma
- Malignant Neoplasms
- Neoplasms
- Fatty Liver
- Intrahepatic Cholestasis
- Diabetes Mellitus
Interacting Proteins
- ESR1
- NCOA1
- PRKDC
- RXRB
- SETD7
Pathways
- Transport
- Lipid Homeostasis
- Pathogenesis
- Cholesterol Homeostasis
- Secretion
- Glucose Homeostasis
- Cell Proliferation
- Energy Homeostasis
- Regeneration
- Excretion
- Intestinal Absorption
- Reverse Transcription
- Cell Cycle
PTMs
- Phosphorylation
Research Areas
- Cancer
- Chromatin Research
- Lipid and Metabolism
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NR1H4
bosterbio.com/bosterbio-gene-info-cards/NR1H4
References
PMID: 12062799 by Huber R.M., et al. Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters.
PMID: 10514450 by Grober J., et al. Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer.