Peroxisomal coenzyme A diphosphatase NUDT7 (Nudt7)

Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with comparable efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'- phosphopantetheine.

Has no activity toward NDP-sugars, CDP- alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA amounts in this organelle in response to metabolic demand.