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- Table of Contents
NEDD4 Antibodies
AND NEDD4 ELISA kits, NEDD4 Proteins
Many biological assays use antibodies to detect NEDD4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NEDD4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NEDD4 antibodies...
Designing a Western blot for NEDD4? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the NEDD4 Western Blot GuideNEDD4 Infographic by Boster Bio
All NEDD4 Products
Product
Figures
Specificity
Applications
Price
Human, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00984-3
100 μg/vial
Cat # A00984-3
100 μg/vial
Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A00984-4
100 μg/vial
Cat # A00984-4
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, ICC, WB
$370
Cat # A01595-1
100 μg/vial
Cat # A01595-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IHC, WB
$370
Cat # M00984
100 μl
Cat # M00984
100 μl
Human, Mouse
Flow Cytometry, IP, WB
$370
Cat # M01597
100 μl/vial
Cat # M01597
100 μl/vial
Human, Mouse
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01598
100 μl
Cat # M01598
100 μl
Human, Mouse, Rat
ELISA, IF, ICC, WB
$481
Cat # A12575-1
0.1 mg
Cat # A12575-1
0.1 mg
Human
ELISA
$540
Cat # EKC2287
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2287
1 kit, containing two 96-well plates and all necessary reagents
NEDD4 Overview
Facts about E3 ubiquitin-protein ligase NEDD4.
E3 ubiquitin-protein ligase NEDD4 (NEDD4)
Specifically ubiquitinates'Lys-63' in target proteins (PubMed:23644597). Involved in the pathway resulting in the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity.
Monoubiquitinates IGF1R at multiple sites, thus resulting in receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, resulting in receptor internalization and degradation in lysosomes.
Gene Information
| Human | |
|---|---|
| Gene Name: | NEDD4 |
| Uniprot: | P46934 |
| Entrez: | 4734 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Cell proliferation-inducing gene 53 protein; E3 ubiquitin-protein ligase NEDD4; EC 6.3.2; EC 6.3.2.-; KIAA0093NEDD4-1MGC176705; NEDD4; NEDD-4; Neural precursor cell expressed developmentally down-regulated protein 4; neural precursor cell expressed, developmentally down-regulated 4; receptor-potentiating factor 1; RPF1
Molecular Weight
Mass (kDA):
149.114 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q21.3 |
| Sequence: | 15; NC_000015.10 (55826917..55993612, complement) |
Subcellular Localizations
Cytoplasm. Cell membrane; Peripheral membrane protein. Recruited to the plasma membrane by GRB10. Once complexed with GRB10 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity). May be recruited to exosomes by NDFIP1.
Diseases
- Hypertensive Disease
- Liddle Syndrome
- Malignant Neoplasms
- Neoplasms
- Hiv Infections
- Atrophy
- Sarcoma
- Immunologic Deficiency Syndromes
- Pseudohypoaldosteronism
- Nervousness
- Cell Transformation, Neoplastic
Interacting Proteins
- EGFR
- FGFR1
- GABARAP
- GABARAPL1
- GABARAPL2
- LITAF
- PTEN
- RNF11
- SCNN1B
- SMURF2
Pathways
- Transport
- Endocytosis
- Localization
- Cell Growth
- Muscle Atrophy
- Pathogenesis
- Protein Ubiquitination
- Cell Proliferation
- Proteolysis
- Cell Cycle
- Rna Interference
- Cell Adhesion
- Translation
PTMs
- Ubiquitination
- Phosphorylation
- Cleavage
- Sumoylation
- Nitrosylation
- Isgylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NEDD4
bosterbio.com/bosterbio-gene-info-cards/NEDD4
References
PMID: 17218260 by Wang X., et al. NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN.
PMID: 11598133 by Pham N., et al. Nedd4 regulates ubiquitination and stability of the guanine- nucleotide exchange factor CNrasGEF.
1 Publications of Boster NEDD4 Antibodies & ELISA Kits
- PubMed ID: 31958096, The Novel Dual GLP-1/GIP Receptor Agonist DA-CH5 Is Superior to Single GLP-1 Rec...
*More publications can be found for each product on its corresponding product page