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- Table of Contents
Protein O-GlcNAcase Antibodies
AND OGA ELISA kits, Protein O-GlcNAcase Proteins
Many biological assays use antibodies to detect Protein O-GlcNAcase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein O-GlcNAcase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein O-GlcNAcase antibodies...
Designing a Western blot for Protein O-GlcNAcase? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the OGA Western Blot GuideDesigning an IHC experiment for Protein O-GlcNAcase? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the OGA IHC GuideOGA Infographic by Boster Bio
All OGA Products
Product
Figures
Specificity
Applications
Price
Anti-MGEA5/OGA Antibody Picoband®
3 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A32463
100 μg/vial
Cat # A32463
100 μg/vial
OGA Overview
Facts about Protein O-GlcNAcase.
Protein O-GlcNAcase (OGA)
Isoform 1: Cleaves GlcNAc but not GalNAc from O- glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4- methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl- beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210).
Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714). .
Gene Information
| Human | |
|---|---|
| Gene Name: | OGA |
| Uniprot: | O60502 |
| Entrez: | 10724 |
Family
| Belongs to: |
|---|
| glycosyl hydrolase 84 family |
Alternative Names
bifunctional protein NCOAT; FLJ11229; GH84; HEXC; HEXC3; Hexosaminidase B; hyaluronidase in meningioma; KIAA0679; MEA5FLJ23355; meningioma expressed antigen 5 (hyaluronidase); Meningioma-expressed antigen 5; MGEA5; NCOAT; Nuclear cytoplasmic O-GlcNAcase and acetyltransferase; OGA; OGlcNAcase; O-GlcNAcase
Molecular Weight
Mass (kDA):
102.915 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q24.32 |
| Sequence: | 10; NC_000010.11 (101784443..101818709, complement) |
Tissue Specificity
Ubiquitous. Shows highest expression in the brain, placenta and pancreas.
Subcellular Localizations
[Isoform 3]: Nucleus.; [Isoform 1]: Cytoplasm.
Diseases
- Neoplasms
- Malignant Neoplasms
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Sarcoma
- Headache
- Malignant Neoplasm Of Urinary Bladder
- Soft Tissue Neoplasms
- Bladder Neoplasm
- Carcinoma
- Fibrosarcoma
- Mammary Neoplasms
Pathways
- Localization
- Methylation
- Pathogenesis
- Aging
- Fertilization
- Dna Methylation
- Regulation Of Gene Expression
- Dosage Compensation
- Embryo Development
PTMs
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/OGA
bosterbio.com/bosterbio-gene-info-cards/OGA
References
PMID: 9811929 by Heckel D., et al. Novel immunogenic antigen homologous to hyaluronidase in meningioma.
PMID: 11341771 by Comtesse N., et al. Identification of a nuclear variant of MGEA5, a cytoplasmic hyaluronidase and a beta-N-acetylglucosaminidase.