Opiorphin prepropeptide Antibodies

AND OPRPN ELISA kits, Opiorphin prepropeptide Proteins

Many biological assays use antibodies to detect Opiorphin prepropeptide, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Opiorphin prepropeptide in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Opiorphin prepropeptide antibodies...

We validate the specificity of these antibodies to Opiorphin prepropeptide by testing them on tissues known to express OPRPN positively and negatively. Browse below to find the OPRPN antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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OPRPN Infographic by Boster Bio

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OPRPN Overview

Facts about Opiorphin prepropeptide.

OPRPN 3D structure. Source: alphafold

Opiorphin prepropeptide (OPRPN)

Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively.

Inhibits the breakdown of Ala- pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a powerful analgesic effect when administered to rats by intravenous injection.

Gene Information

Human
Gene Name:	OPRPN
Uniprot:	Q99935
Entrez:	58503

Family

Belongs to:

PROL1/PROL3 family

Alternative Names

Opiorphin prepropeptide

Molecular Weight

Mass (kDA):
27.217 kDA

Genomic Context


Human

Location:	4q13.3
Sequence:	4; NC_000004.12 (70397940..70410195)

Tissue Specificity

Abundantly expressed in lacrimal gland where it found in the secretory endpieces. Also expressed at modest levels in the submandibular gland.

Subcellular Localizations

Secreted.

PTMs

Glycoprotein

Pyrrolidone carboxylic acid

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/OPRPN

References

PMID: 8670737 by Dickinson D.P., et al. cDNA cloning of an abundant human lacrimal gland mRNA encoding a novel tear protein.

PMID: 25946035 by Azkargorta M., et al. Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification.