Calcium release-activated calcium channel protein 1 (ORAI1)

Ca(2+) release-activated Ca(2+) (CRAC) channel subunit that mediates Ca(2+) influx after depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628, PubMed:28219928). CRAC channels are the most important pathway for Ca(2+) influx in T-cells and encourage the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901).