PABPN1 Antibodies

AND PABPN1 ELISA kits, PABPN1 Proteins

Many biological assays use antibodies to detect PABPN1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PABPN1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PABPN1 antibodies...

We validate the specificity of these antibodies to PABPN1 by testing them on tissues known to express PABPN1 positively and negatively. Browse below to find the PABPN1 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for PABPN1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the PABPN1 Western Blot Guide

Designing an IHC experiment for PABPN1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the PABPN1 IHC Guide

PABPN1 Infographic by Boster Bio

All PABPN1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-PABPN1 Antibody Picoband®

IF analysis of PABPN1 using anti-PABPN1 antibody (A02445-2)

+10

Human, Mouse, Rat

Flow Cytometry, IP, IF, IHC, ICC, WB

$370
Cat # A02445-2
100 μg/vial

Anti-PABPN1 Rabbit Monoclonal Antibody

Western blot analysis of PABPN1 using anti-PABPN1 antibody (M02445)

IHC analysis of PABPN1 using anti-PABPN1 antibody (M02445)

Human, Mouse, Rat

Flow Cytometry, IP, IF, IHC, ICC, WB

$370
Cat # M02445
100 μl

PABPN1L (NM_001080487) Human Over-expression Lysate

Human

$628
Cat # LS390748
20 µg, 100 µg

Human PABPN1 Recombinant Protein

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain

SDS-PAGE, Denatured

$250
Cat # PROTQ86U42
Starting from 20ug

PABPN1L (NM_001080487) Human Recombinant Protein

Coomassie blue staining of purified PABPN1L protein

$1249
Cat # PROTA6NDY0
20 µg

PABPN1 Overview

Facts about Polyadenylate-binding protein 2.

PABPN1 3D structure. Source: alphafold

Polyadenylate-binding protein 2 (PABPN1)

Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation response and controls the poly(A) tail length (By similarity).

Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense- mediated decay (NMD) of mRNA.

Gene Information

Human
Gene Name:	PABPN1
Uniprot:	Q86U42
Entrez:	8106

Family

Belongs to:

No superfamily

Alternative Names

Nuclear poly(A)-binding protein 1; OPMD; PAB2poly(A) binding protein II; PABII; PABP-2; PABP2polyadenylate-binding protein 2; poly(A) binding protein 2; poly(A) binding protein, nuclear 1; Poly(A)-binding protein 2; Poly(A)-binding protein II; poly(A)-binding protein, nuclear 1; Polyadenylate-binding nuclear protein 1

Molecular Weight

Mass (kDA):
32.749 kDA

Genomic Context


Human

Location:	14q11.2
Sequence:	14; NC_000014.9 (23320188..23326185)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Nucleus. Cytoplasm. Nucleus speckle. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between the nucleus and the cytoplasm but predominantly found in the nucleus (PubMed:10688363). Its nuclear import may involve the nucleocytoplasmic transport receptor transportin and a RAN-GTP-sensitive import mechanism (By similarity). Is exported to the cytoplasm by a carrier-mediated pathway that is independent of mRNA traffic. Colocalizes with SKIP and poly(A) RNA in nuclear speckles (By similarity). Intranuclear filamentous inclusions or 'aggregates' are detected in the myo

Diseases

Muscular Dystrophy, Oculopharyngeal
Dystrophy
Muscular Dystrophy
Weakness
Trinucleotide Repeat Expansion
Deglutition Disorders
Blepharoptosis
Muscle Weakness
Myopathy
Neuromuscular Diseases
Abnormal Degeneration
Muscle Degeneration

Hereditary Diseases
Cardiac Fibrillation
Disorders, Late-onset
Neurodegenerative Disorders
Ataxia
Ophthalmopareses

Interacting Proteins

PABPC1
SNW1

Pathways

Translation
Localization
Cell Death
Pathogenesis
Methylation
Transport
Aging
Nuclear Export
Mitosis
Proteolysis
Poly-a Binding
Cell Cycle
Cytoplasmic Translation

Mrna Polyadenylation
Meiosis
Cell Proliferation
Myoblast Proliferation
Hypersensitivity
Muscle Contraction
Mrna Processing

PTMs

Methylation
Cleavage

Acetylation
Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PABPN1

References

PMID: 9462747 by Brais B., et al. Short GCG expansions in the PABP2 gene cause oculopharyngeal muscular dystrophy.

PMID: 10205180 by Chen Z., et al. Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machinery.