PAH Antibodies

Phenylalanine-4-hydroxylase (PAH)

Catalyzes the hydroxylation of L-phenylalanine to L- tyrosine.

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Gene Information

Human
Gene Name:	PAH
Uniprot:	P00439
Entrez:	5053

Family

Belongs to:
biopterin-dependent aromatic amino acid hydroxylase family

Alternative Names

EC 1.14.16; EC 1.14.16.1; PH; phe-4-monooxygenase; phenylalanine 4-monooxygenase; phenylalanine hydroxylase; phenylalanine-4-hydroxylase; PKU; PKU1

Molecular Weight

Mass (kDA):
51.862 kDA

Genomic Context

Human
Location:	12q23.2
Sequence:	12; NC_000012.12 (102836889..102958441, complement)

Diseases

• Hypertensive Disease
• Idiopathic Pulmonary Hypertension
• Pulmonary Hypertension
• Malignant Neoplasms
• Phenylketonurias
• Neoplasms
• Carcinogenesis
• Malignant Neoplasm Of Lung
• Hyperphenylalaninemia
• Kidney Diseases
• Lung Neoplasms

• Salmonella Infections
• Kidney Failure
• Classical Phenylketonuria
• Inflammation
• Heart Failure
• Carcinoma

Pathways

• Transport
• Excretion
• Glomerular Filtration
• Secretion
• Pathogenesis
• Anion Transport
• Organic Anion Transport
• Diuresis
• Vasoconstriction
• Cell Proliferation
• Natriuresis
• Dna Repair
• Localization

• Aging
• Cell Death
• Vasodilation
• Conjugation
• Cell Growth
• Regeneration
• Methylation

PTMs

• Oxidation
• Hydroxylation
• Nitration
• Phosphorylation
• Methylation
• Carboxylation
• Cleavage
• Reduction
• Acetylation
• Bromination

• Demethylation
• Ubiquitination
• Dephosphorylation
• Biotinylation
• Glycosylation
• Deacetylation
• Phosphorothioation
• Deamination
• Iodination
• Myristoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PAH

Boster Bio - Best Uses Of The EU Marker PAH

The Boster Bio has been proven to be an excellent tool for detecting the presence of the EU marker PAH in food supplements and complex matrices. The Boster Bio optimization guide can help you understand the process better, optimize experiments and improve results. It is inevitable to run into problems with your experiments, but proper controls can minimize the impact. The troubleshooting guide in the Boster Bio can help you isolate sources of error.

Detection of PAHs in complex matrices

The detection of PAHs in food and other matrices requires robust method performance validation, which is difficult in the presence of low amounts of these compounds. Optimised sample preparation strategies can be used to minimise contamination. The robustness of GC-HRMS analysis allows further extension of the range of analytes and matrices, which is particularly helpful when toxicological assessments are lacking bcT6urrsmely,of the Es anUS EPAes requiof thS analysie o24of PAts, buf thbcsie oe detectios ar haf lows 1 ng/mLon. ysimakgieshrod mograp whhS analysie of PAHs difficuts, buf t ar arsevericadethniquytesvailitable td improve detectiosxtentinevyes. The Boster Bir PAU markeysie coinatabls witAgielle's J&W Seleteir PAGCie lumnls witaios od mwhhseleterros. ThGCio hae an excellenr denectioOptarsvitilevy, stand the Boster Bir PAU markeysisuevitabll fohigh-d performancS analysT. Thr PAselete(r)es pilculyie lumnls pars ayve rolvedof thesissuicesalmetughin theeaknts ofrip whyellets andhryslletwt arprorlapp However,of thr PAselete(r)es pilculyie lumnlysieapitabls oimpducckine coiritablr PAyieldces. Thf analogicadethniquyon of the Boster Bir PAU markeysis robust in austtne coxtealytefg bcAseleteinevy byie mb mitingwohGCidethniquytT. The Boster Bir PAU markewasisucrocelpfut ir detectinpolycyclwhhS od mwhhhyd prarbonAHs iahe range od sampcese ractinf od oil spilcsen toiod cessurmities. Thfccuracyts ansxtentinevyon of ysimamarkes allowf thS analysie on complex matricse con mitinvariousof PAes. These compounr arfmpouHs iormyonrganwhhx metterincludckine ical andil depoentAes. Tyos ar lsose contaminAbyiroadofarosBeekeeropepracttricseaioslsosaffeteit>The detectios andleanupie of PAT. ThM miFluo-UVeysiaioproaiogvaler-e coinatablfluoe rcesence deteg n ausfargesipolycyclwhhS od mwhhhyd prarbonAts. AHsual-channelve detectiosyBosmls caneasu arupin tf youfluoe rcestof PAes. Io has beelytnAtios sampcnf od degielvfuecal andil impducentsemsxcetsemmamiletwaosteneakeyndoburiicalreases. ThM miFluo-UVet methofccamouAfg 62-97%on of thtoticar PAe ccestparatior.

Detection oe EU marker PsAH in food supplemenes

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