p21-activated protein kinase-interacting protein 1 (PAK1IP1)

Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA.

PAK1 exists as an inactive homodimer, which can be activated by binding of small GTPases such as CDC42 into an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42.