This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
PAN2 Antibodies
AND PAN2 ELISA kits, PAN2 Proteins
Many biological assays use antibodies to detect PAN2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PAN2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PAN2 antibodies...
Designing a Western blot for PAN2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PAN2 Western Blot GuidePAN2 Infographic by Boster Bio
All PAN2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A03834-1
100 µg/vial
Cat # A03834-1
100 µg/vial
PAN2 Overview
Facts about PAN2-PAN3 deadenylation complex catalytic subunit PAN2.
PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (PAN2)
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP).
PAN deadenylation is followed by rapid degradation of the shortened mRNA tails from the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two different mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.
Gene Information
| Human | |
|---|---|
| Gene Name: | PAN2 |
| Uniprot: | Q504Q3 |
| Entrez: | 9924 |
Family
| Belongs to: |
|---|
| peptidase C19 family |
Alternative Names
EC 3.1.13.4; FLJ39360; hPan2; Inactive ubiquitin carboxyl-terminal hydrolase 52; KIAA0710PAB-dependent poly(A)-specific ribonuclease subunit 2; NALP4; PABP-dependent poly(A) nuclease 2; PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae); PAN2 polyA specific ribonuclease subunit; PYPAF4; ubiquitin specific peptidase 52; ubiquitin specific protease 52; USP52
Molecular Weight
Mass (kDA):
135.368 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q13.3 |
| Sequence: | 12; NC_000012.12 (56316223..56334000, complement) |
Subcellular Localizations
Cytoplasm. Cytoplasm, P-body. Nucleus. Shuttles between nucleus and cytoplasm.
Diseases
- Insulin Resistance
- Mycoplasma Pneumonia
- Lyme Disease
- Obesity
- Neoplasms
- Innate Immune Response
- Werner Syndrome
- Inflammation
Interacting Proteins
- PAN3
- TNRC6C
Pathways
- Translation
- Localization
- Telomere Binding
- Cell Division
- Cell Cycle
- Innate Immune Response
- Dna Repair
- Immune Response
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PAN2
bosterbio.com/bosterbio-gene-info-cards/PAN2
References
PMID: 14583602 by Uchida N., et al. Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein.
PMID: 14715245 by Quesada V., et al. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.