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- Table of Contents
Facts about Partitioning defective 6 homolog alpha.
Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802).
Human | |
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Gene Name: | PARD6A |
Uniprot: | Q9NPB6 |
Entrez: | 50855 |
Belongs to: |
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PAR6 family |
PAR-6 alpha; par-6 partitioning defective 6 homolog alpha (C. elegans); PAR-6; PAR6A; PAR6alpha; PAR-6Apar-6 (partitioning defective 6, C.elegans) homolog alpha; PAR6C; partitioning defective 6 homolog alpha; partitioning defective-6 homolog alpha; partitioning-defective protein 6; Tax interaction protein 40; TAX40; Tax-interacting protein 40; TIP-40PAR6
Mass (kDA):
37.388 kDA
Human | |
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Location: | 16q22.1 |
Sequence: | 16; NC_000016.10 (67660956..67662774) |
Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta.
Cytoplasm. Cell membrane. Cell projection, ruffle. Cell junction, tight junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Colocalizes with GTP-bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions. Recruited to the centrosome by a microtubule and dynein-dynactin-dependent mechanism.
PMID: 10954424 by Johansson A.-S., et al. The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1.
PMID: 10873802 by Qiu R.-G., et al. A human homolog of the Caenorhabditis elegans polarity determinant Par-6 links Rac and Cdc42 to PKC-zeta signaling and cell transformation.