PAX-interacting protein 1 Antibodies

AND PAXIP1 ELISA kits, PAX-interacting protein 1 Proteins

Many biological assays use antibodies to detect PAX-interacting protein 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PAX-interacting protein 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PAX-interacting protein 1 antibodies...

We validate the specificity of these antibodies to PAX-interacting protein 1 by testing them on tissues known to express PAXIP1 positively and negatively. Browse below to find the PAXIP1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PAXIP1 Infographic by Boster Bio

All PAXIP1 Products

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Specificity

Applications

Price

Anti-GAS PAGR1 Antibody

Western blot analysis of GAS in EL4 cell lysate in (A) the absence and (B) the presence of blocking peptide with GAS antibody at 1μg/mL

Human, Mouse

ELISA, WB

$481
Cat # A13756
0.1 mg

PTIP (PAXIP1) (NM_007349) Human Over-expression Lysate

Human

$960
Cat # LS022976
20 µg, 100 µg

PAXIP1 Overview

Facts about PAX-interacting protein 1.

PAXIP1 3D structure. Source: alphafold

PAX-interacting protein 1 (PAXIP1)

Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development.

In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs).

Gene Information

Human
Gene Name:	PAXIP1
Uniprot:	Q6ZW49
Entrez:	22976

Family

Belongs to:

No superfamily

Alternative Names

CAGF28; PACIP1; PAX interacting (with transcription-activation domain) protein 1; PAX transactivation activation domain-interacting protein; PAX transcription activation domain interacting protein 1 like; PAX-interacting protein 1; PAXIP1LCAGF29; protein encoded by CAG trinucleotide repeats; PTIPFLJ41049; TNRC2

Molecular Weight

Mass (kDA):
121.341 kDA

Genomic Context


Human

Location:	7q36.2
Sequence:	7; NC_000007.14 (154943690..155003419, complement)

Subcellular Localizations

Nucleus matrix. Chromosome. Localizes to DNA damage foci upon ionizing radiation.

Diseases

Ataxia
Malignant Neoplasms
Neoplasms
Leukemia
Malignant Neoplasm Of Ovary
Disease Of Adrenal Medulla
Cardiac Arrhythmia
Premature Ventricular Contractions
Proteinuria Of Undiagnosed Cause
Trinucleotide Repeat Expansion
Heart Failure
Genomic Instability

Hyperosmolality
Osteosarcoma
Tumor Angiogenesis
Pyotraumatic Dermatitis
Obesity
Kidney Diseases
Alzheimer's Disease

Interacting Proteins

ASH2L
H2AFX
MAPRE2
NXT1
PAGR1

POM121
RBBP5
TP53BP1
WDR5

Pathways

Methylation
Dna Repair
Localization
Dna Recombination
Cell Cycle
Histone Methylation
Dna Replication
Transport
Cell Cycle Checkpoint
Gene Silencing
Cellular Homeostasis
Protein Targeting
Histone Modification

Regulation Of Gene Expression
Vasculogenesis
V(d)j Recombination
Cell Fate Specification
Tissue Development
Translesion Synthesis
Segmentation

PTMs

Methylation
Phosphorylation
Sumoylation

Cleavage
Acetylation
Ubiquitination

Research Areas

Cancer
DNA Repair

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PAXIP1

References

PMID: 9225980 by Margolis R.L., et al. cDNAs with long CAG trinucleotide repeats from human brain.

PMID: 11940591 by Hoffmeister A., et al. The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans- activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter.