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- Table of Contents
PDCD6IP Antibodies
AND PDCD6IP ELISA kits, PDCD6IP Proteins
Many biological assays use antibodies to detect PDCD6IP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDCD6IP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDCD6IP antibodies...
Designing a Western blot for PDCD6IP? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PDCD6IP Western Blot GuidePDCD6IP Infographic by Boster Bio
All PDCD6IP Products
Product
Figures
Specificity
Applications
Price
Anti-ALIX/PDCD6IP Antibody Picoband®
4 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9770
100 μg/vial
Cat # PB9770
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01751-1
100 μg/vial
Cat # M01751-1
100 μg/vial
Anti-ALIX Rabbit Monoclonal Antibody
4 Citations
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # M01751
100 μl
Cat # M01751
100 μl
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M01751-4
20μL, 40μL, 100μL, 200μL
Cat # M01751-4
20μL, 40μL, 100μL, 200μL
PDCD6IP Overview
Facts about Programmed cell death 6-interacting protein.
Programmed cell death 6-interacting protein (PDCD6IP)
Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome.
Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459).
Gene Information
| Human | |
|---|---|
| Gene Name: | PDCD6IP |
| Uniprot: | Q8WUM4 |
| Entrez: | 10015 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
AIP1DRIP4; ALG-2 interacting protein 1; ALG-2 interacting protein X; ALG-2-interacting protein 1; alinx; Alix; apoptosis-linked gene 2-interacting protein X; dopamine receptor interacting protein 4; HP95; KIAA1375; MGC17003; PDCD6-interacting protein; programmed cell death 6 interacting protein; programmed cell death 6-interacting protein
Molecular Weight
Mass (kDA):
96.023 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p22.3 |
| Sequence: | 3; NC_000003.12 (33798571..33869707) |
Subcellular Localizations
Cytoplasm, cytosol. Melanosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Secreted, extracellular exosome. Cell junction, tight junction. Midbody, Midbody ring. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Colocalized with CEP55 at centrosomes of non-dividing cells. Component of the actomyosin-tight junction complex (By similarity). PDCD6IP targeting to the midbody requires the interaction with CEP55 (PubMed:18641129).
Diseases
- Hiv Infections
- Neoplasms
- Tissue Adhesions
- Anemia
- Equine Infectious Anemia
- Immunologic Deficiency Syndromes
- Virus Diseases
- Malignant Paraganglionic Neoplasm
- Hepatitis B
- Carcinoma
- Malignant Neoplasms
- Hepatitis
Interacting Proteins
- CD2AP
- CEP55
- CHMP4A
- CHMP4B
- Chmp4b
- CHMP4C
- FYN
- HCK
- Hoxa1
- LGALS3
Pathways
- Transport
- Cell Death
- Cytokinesis
- Abscission
- Cell Adhesion
- Membrane Fission
- Programmed Cell Death
- Endocytosis
- Cell Division
- Localization
- Cell Proliferation
- Oocyte Maturation
- Rna Interference
PTMs
- Phosphorylation
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDCD6IP
bosterbio.com/bosterbio-gene-info-cards/PDCD6IP
References
PMID: 11683497 by Wu Y., et al. Overexpression of Hp95 induces G1 phase arrest in confluent HeLa cells.
PMID: 19906316 by Wang P., et al. Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site.
1 Publications of Boster PDCD6IP Antibodies & ELISA Kits
- PubMed ID: 32400849, Cao G,Meng X, Han X,Li J.Exosomes derived from circRNA Rtn4-modified BMSCs atten...
*More publications can be found for each product on its corresponding product page