PDE6A Antibodies

AND PDE6A ELISA kits, PDE6A Proteins

Many biological assays use antibodies to detect PDE6A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDE6A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDE6A antibodies...

We validate the specificity of these antibodies to PDE6A by testing them on tissues known to express PDE6A positively and negatively. Browse below to find the PDE6A antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PDE6A Infographic by Boster Bio

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Anti-PDE6 alpha/PDE6A Antibody Picoband®

Western blot analysis of PDE6 alpha/PDE6A using anti-PDE6 alpha/PDE6A antibody (A07800-1)

IHC analysis of PDE6 alpha/PDE6A using anti-PDE6 alpha/PDE6A antibody (A07800-1)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A07800-1
100 μg/vial

PDE6A Overview

Facts about Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha.

PDE6A 3D structure. Source: alphafold

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (PDE6A)

This protein participates in processes of transmission and amplification of the visual signal. .

Gene Information

Human
Gene Name:	PDE6A
Uniprot:	P16499
Entrez:	5145

Family

Belongs to:

cyclic nucleotide phosphodiesterase family

Alternative Names

CGPR-A; EC 3.1.4; EC 3.1.4.35; GMP-PDE alpha; PDE V-B1; PDEAcGMP phosphodiesterase alpha subunit; phosphodiesterase 6A, cGMP-specific, rod, alpha; rod cGMP-specific 3'-5'-cyclic phosphodiesterase subunit alpha; rod photoreceptor cGMP phosphodiesterase alpha subunit; RP43

Molecular Weight

Mass (kDA):
99.547 kDA

Genomic Context


Human

Location:	5q32
Sequence:	5; NC_000005.10 (149857953..149944793, complement)

Subcellular Localizations

Cell membrane; Lipid-anchor; Cytoplasmic side.

Diseases

Retinitis Pigmentosa
Retinal Degeneration
Dog Diseases
Atrophy
Atrophic Retina
Blind Vision
Dysplasia
Retinal Diseases
Retinal Dystrophies
Amaurosis
Macular Edema, Cystoid
Edema

Macular Retinal Edema
Dystrophy
Leber Congenital Amaurosis
Night Blindness
Retinal Dysplasia
Degenerative Disorder

Pathways

Phototransduction
Pathogenesis
Hypersensitivity
Reflex

PTMs

Acetylation
Lipoprotein

Methylation
Prenylation

Research Areas

Signal Transduction
Vision

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDE6A

References

PMID: 2155175 by Pittler S.J., et al. Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene.

PMID: 7493036 by Huang S.H., et al. Autosomal recessive retinitis pigmentosa caused by mutations in the alpha subunit of rod cGMP phosphodiesterase.