E3 ubiquitin-protein ligase pellino homolog 3 (Peli3)

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways through interaction with the complex containing IRAK kinases and TRAF6.

Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can trigger AP1/JUN and ELK1.