PIGN Antibodies

AND PIGN ELISA kits, PIGN Proteins

Many biological assays use antibodies to detect PIGN, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PIGN in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PIGN antibodies...

We validate the specificity of these antibodies to PIGN by testing them on tissues known to express PIGN positively and negatively. Browse below to find the PIGN antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PIGN Infographic by Boster Bio

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PIGN (NM_176787) Human Over-expression Lysate

PIGN Human Over-expression Lysates NM_012327

Human

$628
Cat # LS023556
20 µg, 100 µg

PIGN Overview

Facts about GPI ethanolamine phosphate transferase 1.

PIGN 3D structure. Source: alphafold

GPI ethanolamine phosphate transferase 1 (PIGN)

Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity).

May act as suppressor of replication stress and chromosome missegregation. .

Gene Information

Human
Gene Name:	PIGN
Uniprot:	O95427
Entrez:	23556

Family

Belongs to:

PIGG/PIGN/PIGO family

Alternative Names

EC 2.-; GPI ethanolamine phosphate transferase 1; MCD4 homolog; MCD4; MDC4; MGC26427; phosphatidylinositol glycan anchor biosynthesis, class N; Phosphatidylinositol-glycan biosynthesis class N protein; PIG-Nphosphatidylinositol glycan, class N

Molecular Weight

Mass (kDA):
105.81 kDA

Genomic Context


Human

Location:	18q21.33
Sequence:	18; NC_000018.10 (62041164..62187118, complement)

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

Glomerulonephritis
Nephritis
Lupus Erythematosus, Systemic
Lupus Nephritis
Glomerulonephritis, Membranoproliferative
Kidney Diseases
Macular Corneal Dystrophy Type I
Segmental Glomerulosclerosis
Focal Glomerulosclerosis
Glomerulonephritis, Minimal Change
Glomerulosclerosis (disorder)
Membranous Glomerulonephritis

Nephrotic Syndrome
Congenital Abnormality
Muscle Hypotonia
Iga Glomerulonephritis
Proteinuria Of Undiagnosed Cause
Developmental Delay (disorder)
Kidney Failure, Chronic

Pathways

Pathogenesis
Tissue Development
Cell Cycle
Response To Hypoxia
Dna Repair
Hypersensitivity
Angiogenesis
Forebrain Development

Cytokinesis
Ion Homeostasis

PTMs

Gpi Anchoring

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PIGN

References

PMID: 10069808 by Gaynor E.C., et al. MCD4 encodes a conserved endoplasmic reticulum membrane protein essential for glycosylphosphatidylinositol anchor synthesis in yeast.

PMID: 23446422 by Burrell R.A., et al. Replication stress links structural and numerical cancer chromosomal instability.