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- Table of Contents
PIK3CG Antibodies
AND PIK3CG ELISA kits, PIK3CG Proteins
Many biological assays use antibodies to detect PIK3CG, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PIK3CG in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PIK3CG antibodies...
Designing an IHC experiment for PIK3CG? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PIK3CG IHC GuidePIK3CG Infographic by Boster Bio
All PIK3CG Products
Product
Figures
Specificity
Applications
Price
Anti-PI3K-gamma/PIK3CG Antibody Picoband®
8 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A01517-2
100 μg/vial
Cat # A01517-2
100 μg/vial
Human
$628
Cat # LS005294
20 µg, 100 µg
Cat # LS005294
20 µg, 100 µg
PIK3CG Overview
Facts about Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform.
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG)
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins into the membrane, including AKT1 and PDPK1, triggering signaling cascades involved in cell growth, survival, proliferation, motility and morphology.
Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic reactions.
Gene Information
| Human | |
|---|---|
| Gene Name: | PIK3CG |
| Uniprot: | P48736 |
| Entrez: | 5294 |
Family
| Belongs to: |
|---|
| PI3/PI4-kinase family |
Alternative Names
1-phosphatidylinositol 3-kinase; EC 2.7.1; EC 2.7.1.153; p110-gamma; p120-PI3K; phosphatidylinositol 3 kinase gamma, p110 gamma; phosphatidylinositol 3-kinase catalytic 110-kD gamma; phosphatidylinositol 3-kinase, catalytic, gamma polypeptide; Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphoinositide-3-kinase gamma catalytic subunit; phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI 3Kinase p110 gamma; PI 3-Kinase p110 gamma; PI3CG; PI3K; PI3K-gamma ; PI3Kgamma; PI3K
Molecular Weight
Mass (kDA):
126.454 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q22.3 |
| Sequence: | 7; NC_000007.14 (106865282..106908980) |
Tissue Specificity
Pancreas, skeletal muscle, liver and heart.
Subcellular Localizations
Cytoplasm. Cell membrane.
Diseases
- Inflammation
- Tissue Adhesions
- Malignant Neoplasms
- Neoplasms
- Autoimmune Reaction
- Heart Failure
- Arthritis
- Asthma
- Edema
- Rheumatoid Arthritis
- Cell Transformation, Neoplastic
- Pneumonia
- Infarction
Interacting Proteins
- PDE3B
- Pik3r6
Pathways
- Chemotaxis
- Cell Migration
- Secretion
- Cell Proliferation
- Localization
- Cell Motility
- Pathogenesis
- Angiogenesis
- Cell Activation
- Neutrophil Chemotaxis
- Inflammatory Response
- Cell Growth
- Platelet Aggregation
PTMs
- Phosphorylation
- Dephosphorylation
- Demethylation
Research Areas
- mTOR Pathway
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PIK3CG
bosterbio.com/bosterbio-gene-info-cards/PIK3CG
References
PMID: 7624799 by Stoyanov B., et al. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase.
PMID: 11416136 by Gu C., et al. The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity- independent manner.
10 Publications of Boster PIK3CG Antibodies & ELISA Kits
- PubMed ID: 10.3892/mmr.2021.11938, Hydrogen sulfide ameliorates doxorubicin‑induced myocardial fibrosis in rats v...
- PubMed ID: 10.1111/aor.13622, Avβ3 single‐stranded DNA aptamer attenuates vascular restenosis via Ras‐PI3...
- PubMed ID: 10.1016/j.jare.2021.09.001, A comparative study of Mesenchymal Stem Cells transplantation approach to antago...
- PubMed ID: 10.1016/j.envpol.2021.116556, Mechanisms underlying reproductive toxicity induced by nickel nanoparticles iden...
- PubMed ID: 33649809, Nie L,Liu M,Chen J,Wu Q,Li Y,Yi J,Zheng X,Zhang J,Chu C,Yang J.Hydrogen sulfide ...
- PubMed ID: 33654381, Xu Y,Chen W,Chen Z,Huang M,Yang F,Zhang Y.Mechanism of Action of Xiaoyao San in ...
- PubMed ID: -, Lu Kong,Yongya Wu,Wangcheng Hu,Lin Liu,Yuying Xue,Geyu Liang,Mechanisms underlyi...
- PubMed ID: 32990282, Han F,Xu H,Shen JX,Pan C,Yu ZH,Chen JJ,Zhu XL,Cai YF,Lu YP.RhoA/Rock2/Limk1/cofi...
- PubMed ID: 33382670, Chen H,Sheng H,Zhao Y,Zhu G.Piperine Inhibits Cell Proliferation and Induces Apo...
- PubMed ID: 32243998, Amin N,Xie S,Tan X,Chen Y,Ren Q,Botchway BOA,Hu S,Ma Y,Hu Z,Fang M.Optimized int...
*More publications can be found for each product on its corresponding product page