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- Table of Contents
PIK3R2 Antibodies
AND PIK3R2 ELISA kits, PIK3R2 Proteins
Many biological assays use antibodies to detect PIK3R2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PIK3R2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PIK3R2 antibodies...
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PIK3R2 Infographic by Boster Bio
All PIK3R2 Products
Product
Figures
Specificity
Applications
Price
Anti-PI 3 Kinase p85 beta/PIK3R2 Antibody Picoband®
2 Citations 1 Q&As
Human
Flow Cytometry, WB
$370
Cat # PB9777
100 μg/vial
Cat # PB9777
100 μg/vial
Anti-PI 3 Kinase p85 beta/PIK3R2 Antibody Picoband®
1 Citations 5 Q&As
Human, Mouse, Rat
IHC, WB
$370
Cat # PA1680
100 μg/vial
Cat # PA1680
100 μg/vial
Human, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M03363
100 μl
Cat # M03363
100 μl
Human, Mouse, Rat
ELISA, WB
$380
Cat # A03363Y464
100ul
Cat # A03363Y464
100ul
Human
$628
Cat # LS005296
20 µg, 100 µg
Cat # LS005296
20 µg, 100 µg
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M03363-2
100 μl/vial
Cat # M03363-2
100 μl/vial
PIK3R2 Overview
Facts about Phosphatidylinositol 3-kinase regulatory subunit beta.
Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2)
Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5- trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, such as AKT1 and PDPK1, triggering signaling cascades involved in cell growth, survival, proliferation, motility and morphology.
Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317).
Gene Information
| Human | |
|---|---|
| Gene Name: | PIK3R2 |
| Uniprot: | O00459 |
| Entrez: | 5296 |
Family
| Belongs to: |
|---|
| PI3K p85 subunit family |
Alternative Names
P85B; p85-beta; phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; phosphatidylinositol 3-kinase regulatory subunit beta; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta); phosphoinositide-3-kinase, regulatory subunit 2 (beta); phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta); phosphoinositide-3-kinase, regulatory subunit, polypeptide 2 (p85 beta); PI 3Kinase p85 beta; PI 3-Kinase p85 beta; PI3K regulatory subunit beta; PI3-kinase regulatory subunit beta; PI3-kinase subunit p85-beta; PIK3R2; ptdIns-3-kinase regulatory subunit beta; ptdIns-3-kinas
Molecular Weight
Mass (kDA):
81.545 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.11 |
| Sequence: | 19; NC_000019.10 (18153163..18170532) |
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Carcinoma
- Mammary Neoplasms
- Mutation Abnormality
- Tumor Angiogenesis
- Ovarian Neoplasm
- Impaired Glucose Tolerance
- Tumor Progression
- Endometrial Neoplasms
- Endometrial Polyp
Interacting Proteins
- AR
- CBL
- DYDC1
- EGFR
- ERBB2
- ERBB3
- GAB1
- GOLGA2
- GRB2
- HTT
Pathways
- Secretion
- Angiogenesis
- Pathogenesis
- Insulin Receptor Signaling Pathway
- Insulin Secretion
- Brain Development
- Vasculogenesis
- Inflammatory Response
- Cell Division
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PIK3R2
bosterbio.com/bosterbio-gene-info-cards/PIK3R2
References
PMID: 1314371 by Volinia S., et al. Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta.
PMID: 9582025 by Janssen J.W.G., et al. An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme.
2 Publications of Boster PIK3R2 Antibodies & ELISA Kits
- PubMed ID: 10.1189/jlb.1A1215-541RR, PI3K p85 β regulatory subunit deficiency does not affect NK cell differentiatio...
- PubMed ID: 33654381, Xu Y,Chen W,Chen Z,Huang M,Yang F,Zhang Y.Mechanism of Action of Xiaoyao San in ...
*More publications can be found for each product on its corresponding product page