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- Table of Contents
Facts about E3 ubiquitin-protein ligase Praja-2.
Essential for PKA- mediated long-term memory systems. .
| Human | |
|---|---|
| Gene Name: | PJA2 |
| Uniprot: | O43164 |
| Entrez: | 9867 |

| Belongs to: |
|---|
| No superfamily |

E3 ubiquitin-protein ligase Praja-2; EC 6.3.2; EC 6.3.2.-; KIAA0438praja2; Neurodap1; praja ring finger 2; Praja2; RING finger protein 131praja 2, RING-H2 motif containing; RNF131
Mass (kDA):
78.214 kDA

| Human | |
|---|---|
| Location: | 5q21.3 |
| Sequence: | 5; NC_000005.10 (109334709..109409978, complement) |
Cytoplasm. Cell membrane. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, postsynaptic density. Localizes at the cytoplasmic side of endoplasmic reticulum and Golgi apparatus. Expressed in the postsynaptic density region of synapses (By similarity). Colocalizes with PRKAR2A and PRKAR2B in the cytoplasm and the cell membrane.





PMID: 12036302 by Yu P., et al. PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain.
PMID: 21423175 by Lignitto L., et al. Control of PKA stability and signalling by the RING ligase praja2.