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- Table of Contents
Plakophilin-2 Antibodies
AND PKP2 ELISA kits, Plakophilin-2 Proteins
Many biological assays use antibodies to detect Plakophilin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Plakophilin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Plakophilin-2 antibodies...
Designing a Western blot for Plakophilin-2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PKP2 Western Blot GuideDesigning an IHC experiment for Plakophilin-2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PKP2 IHC GuidePKP2 Infographic by Boster Bio
All PKP2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02146-2
100 µg/vial
Cat # A02146-2
100 µg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A02146-1
100 µg/vial
Cat # A02146-1
100 µg/vial
Human
$628
Cat # LS005318
20 µg, 100 µg
Cat # LS005318
20 µg, 100 µg
PKP2 Overview
Facts about Plakophilin-2.
Plakophilin-2 (PKP2)
May play a role in junctional plaques. .
Gene Information
| Human | |
|---|---|
| Gene Name: | PKP2 |
| Uniprot: | Q99959 |
| Entrez: | 5318 |
Family
| Belongs to: |
|---|
| beta-catenin family |
Alternative Names
ARVD9; MGC177501; plakophilin 2; plakophilin-2
Molecular Weight
Mass (kDA):
97.415 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12p11.21 |
| Sequence: | 12; NC_000012.12 (32790746..32896846, complement) |
Tissue Specificity
Detected in heart right ventricle (at protein level). Widely expressed. Found at desmosomal plaques in simple and stratified epithelia and in non-epithelial tissues such as myocardium and lymph node follicles. In most stratified epithelia found in the desmosomes of the basal cell layer and seems to be absent from suprabasal strata.
Subcellular Localizations
Nucleus. Cell junction, desmosome. Nuclear and associated with desmosomes.
Diseases
- Arrhythmogenic Right Ventricular Dysplasia
- Cardiomyopathies
- Cardiac Arrhythmia
- Neoplasms
- Dental Plaque
- Sudden Cardiac Death
- Sudden Death
- Tissue Adhesions
- Tachycardia, Ventricular
- Heart Diseases
- Cardiac Death
- Carcinoma
Interacting Proteins
- MTUS2
- NDEL1
Pathways
- Localization
- Pathogenesis
- Cell Adhesion
- Desmosome Assembly
- Cell-cell Adhesion
- Cell Migration
- Cell Proliferation
- Cell Growth
- Dna Repair
- Immune Response
- Spermatogenesis
- Embryo Development
- Translation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PKP2
bosterbio.com/bosterbio-gene-info-cards/PKP2
References
PMID: 8922383 by Mertens C., et al. Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque.
PMID: 10374264 by Mertens C., et al. Desmosomal plakophilin 2 as a differentiation marker in normal and malignant tissues.