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- Table of Contents
Phospholipid scramblase 1 Antibodies
AND PLSCR1 ELISA kits, Phospholipid scramblase 1 Proteins
Many biological assays use antibodies to detect Phospholipid scramblase 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Phospholipid scramblase 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Phospholipid scramblase 1 antibodies...
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PLSCR1 Infographic by Boster Bio
All PLSCR1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA, IHC, WB
$370
Cat # A02995-2
100 μg/vial
Cat # A02995-2
100 μg/vial
SDS-PAGE
$275
Cat # PROTO15162
Starting from 10ug
Cat # PROTO15162
Starting from 10ug
Human
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # M02995-1
100 μl/vial
Cat # M02995-1
100 μl/vial
Human
$628
Cat # LS005359
20 µg, 100 µg
Cat # LS005359
20 µg, 100 µg
PLSCR1 Overview
Facts about Phospholipid scramblase 1.
Phospholipid scramblase 1 (PLSCR1)
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | PLSCR1 |
| Uniprot: | O15162 |
| Entrez: | 5359 |
Family
| Belongs to: |
|---|
| phospholipid scramblase family |
Alternative Names
Erythrocyte phospholipid scramblase; MMTRA1B; MMTRA1BCa(2+)-dependent phospholipid scramblase 1; Phospholipid Scramblase 1; PL scramblase 1; PLSCR1
Molecular Weight
Mass (kDA):
35.049 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q24 |
| Sequence: | 3; NC_000003.12 (146515178..146544805, complement) |
Tissue Specificity
Expressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle.
Subcellular Localizations
Cell membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor; Cytoplasmic side. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Localizes to the perinuclear region in the presence of RELT.
Diseases
- Malignant Neoplasms
- Neoplasms
- Leukemia
- Carcinoma
- Acute Promyelocytic Leukemia
- Liver Carcinoma
- Hepatitis
- Lupus Erythematosus, Systemic
- Rheumatoid Arthritis
- Adenocarcinoma
- Malignant Paraganglionic Neoplasm
- Hepatitis C
- Autoimmune Diseases
Interacting Proteins
- CATSPER1
- CHRD
- CPSF6
- CTSZ
- DAZAP2
- DEF6
- DMRT3
- DOCK2
- ESR2
- EWSR1
Pathways
- Localization
- Cell Proliferation
- Cell Activation
- Nuclear Import
- Cell Death
- Coagulation
- Pathogenesis
- Secretion
- Immune Response
- Phospholipid Scrambling
- Blood Coagulation
- Cell Growth
- Rna Interference
PTMs
- Phosphorylation
- Palmitoylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLSCR1
bosterbio.com/bosterbio-gene-info-cards/PLSCR1
References
PMID: 9218461 by Zhou Q., et al. Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids.
PMID: 9712717 by Kasukabe T., et al. Identity of human normal counterpart (MmTRA1b) of mouse leukemogenesis-associated gene (MmTRA1a) product as plasma membrane phospholipid scramblase and chromosome mapping of the human MmTRA1b/phospholipid scramblase gene.