Pro-MCH Antibodies

AND PMCH ELISA kits, Pro-MCH Proteins

Many biological assays use antibodies to detect Pro-MCH, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Pro-MCH in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Pro-MCH antibodies...

We validate the specificity of these antibodies to Pro-MCH by testing them on tissues known to express PMCH positively and negatively. Browse below to find the PMCH antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for Pro-MCH? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the PMCH IHC Guide

PMCH Infographic by Boster Bio

All PMCH Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

MCH (PMCH) (NM_002674) Human Over-expression Lysate

Human

$628
Cat # LS005367
20 µg, 100 µg

Anti-Pro-MCH PMCH Antibody

Immunohistochemical analysis of paraffin-embedded human-testis, antibody was diluted at 1:200

Human, Mouse, Rat

ELISA, IF, IHC

$399
Cat # A07730
100μl

PMCH Overview

Facts about Pro-MCH.

PMCH 3D structure. Source: alphafold

Pro-MCH (PMCH)

MCH may function as a neurotransmitter or neuromodulator in a wide array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general stimulation. May also have a part in spermatocyte differentiation.

Gene Information

Human
Gene Name:	PMCH
Uniprot:	P20382
Entrez:	5367

Family

Belongs to:

melanin-concentrating hormone family

Alternative Names

MCHpro-MCH; pro-melanin-concentrating hormone

Molecular Weight

Mass (kDA):
18.679 kDA

Genomic Context


Human

Location:	12q23.2
Sequence:	12; NC_000012.12 (102196459..102199540, complement)

Tissue Specificity

Predominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and cerebellum. Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes and Sertoli cells). No expression in peripheral blood. In brain exclusively mature MCH and NEI peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly.

Subcellular Localizations

Secreted.

Diseases

Obesity
Schizophrenia
Hyperphagia
Diabetes Mellitus
Psychotic Disorders
Liver Diseases
Stillbirth
Keratosis Follicularis
Neurodegenerative Disorders
Leishmaniasis, Visceral
Pediatric Obesity
Malignant Neoplasm Of Urinary Bladder

Respiratory Distress
Hemolysis (disorder)
Cardiovascular Diseases
Malignant Neoplasms
Nervousness
Pituitary Diseases
Asthma

Pathways

Energy Homeostasis
Localization
Pigmentation
Feeding Behavior
Regulation Of Energy Homeostasis
Cell Development
Neurogenesis
Synaptic Transmission
Metaphase

Cell Cycle
Regulation Of Appetite
Pathogenesis
Sensory Perception

PTMs

Amidation

Research Areas

Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PMCH

References

PMID: 2149166 by Presse F., et al. Structure of the human melanin concentrating hormone mRNA.

PMID: 8326825 by Breton C., et al. Isolation and characterization of the human melanin-concentrating hormone gene and a variant gene.