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- Table of Contents
PNP Antibodies
AND PNP ELISA kits, PNP Proteins
Many biological assays use antibodies to detect PNP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PNP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PNP antibodies...
Designing a Western blot for PNP? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PNP Western Blot GuidePNP Infographic by Boster Bio
All PNP Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A05460-1
100 μg/vial
Cat # A05460-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # A00988-1
100 μg/vial
Cat # A00988-1
100 μg/vial
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A04071-2
100 µg/vial
Cat # A04071-2
100 µg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00988-2
100 µg/vial
Cat # A00988-2
100 µg/vial
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # A01800-1
100 μg/vial
Cat # A01800-1
100 μg/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M01800-1
20μL, 40μL, 100μL, 200μL
Cat # M01800-1
20μL, 40μL, 100μL, 200μL
Human
$628
Cat # LS004860
20 µg, 100 µg
Cat # LS004860
20 µg, 100 µg
Human
$628
Cat # LS057104
20 µg, 100 µg
Cat # LS057104
20 µg, 100 µg
PNP Overview
Facts about Purine nucleoside phosphorylase.
Purine nucleoside phosphorylase (PNP)
The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the creation of the corresponding free purine bases and pentose-1-phosphate. .
Gene Information
| Human | |
|---|---|
| Gene Name: | PNP |
| Uniprot: | P00491 |
| Entrez: | 4860 |
Family
| Belongs to: |
|---|
| PNP/MTAP phosphorylase family |
Alternative Names
EC 2.4.2.1; FLJ94043; FLJ97288; Inosine phosphorylase; MGC117396; MGC125915; MGC125916; NPFLJ97312; nucleoside phosphorylase; PNP; PRO1837; PUNP; purine nucleoside phosphorylase; purine-nucleoside:orthophosphate ribosyltransferase
Molecular Weight
Mass (kDA):
32.118 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q11.2 |
| Sequence: | 14; NC_000014.9 (20469406..20477089) |
Tissue Specificity
Expressed in red blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non- spherocytic hemolytic anemia of unknown etiology.
Subcellular Localizations
Cytoplasm, cytoskeleton. Cytoplasm.
Diseases
- Neoplasms
- Immunologic Deficiency Syndromes
- Malignant Neoplasms
- Purine-nucleoside Phosphorylase Deficiency
- Leukemia
- Lymphoma
- Polyneuropathy
- Autoimmune Reaction
- Lymphoid Leukemia
- Lupus Erythematosus, Systemic
- Paraneoplastic Syndromes
Pathways
- Transport
- Excretion
- Conjugation
- Cell Proliferation
- Pathogenesis
- Cell Growth
- Cell Death
- Immune Response
- Localization
- Translation
- Coagulation
- Cell Killing
- Sulfation
PTMs
- Cleavage
- Phosphorylation
- Oxidation
- Hydroxylation
- Reduction
- Nitration
- Deamination
- Dephosphorylation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PNP
bosterbio.com/bosterbio-gene-info-cards/PNP
References
PMID: 6087295 by Williams S.R., et al. Human purine nucleoside phosphorylase cDNA sequence and genomic clone characterization.
PMID: 3029074 by Williams S.R., et al. A human purine nucleoside phosphorylase deficiency caused by a single base change.