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Induces the creation of apical actin-dependent microvilli. Involved in the creation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation through renal tubulogenesis.
|Sequence:||7; NC_000007.14 (131500271..131556628, complement)|
Glomerular epithelium cell (podocyte).
Apical cell membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus. Membrane raft. Membrane; Single-pass type I membrane protein. In single attached epithelial cells is restricted to a preapical pole on the free plasma membrane whereas other apical and basolateral proteins are not yet polarized. Colocalizes with SLC9A3R2 at the apical plasma membrane during epithelial polarization. Colocalizes with SLC9A3R1 at the trans-Golgi network (transiently) and at the apical plasma membrane. Its association with the membrane raft is t