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POLR3A Antibodies
AND POLR3A ELISA kits, POLR3A Proteins
Many biological assays use antibodies to detect POLR3A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with POLR3A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop POLR3A antibodies...
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POLR3A Overview
Facts about DNA-directed RNA polymerase III subunit RPC1.
DNA-directed RNA polymerase III subunit RPC1 (POLR3A)
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III.
Gene Information
| Human | |
|---|---|
| Gene Name: | POLR3A |
| Uniprot: | O14802 |
| Entrez: | 11128 |
Family
| Belongs to: |
|---|
| RNA polymerase beta' chain family |
Alternative Names
DNA-directed RNA polymerase III largest subunit; DNA-directed RNA polymerase III subunit A; DNA-directed RNA polymerase III subunit RPC1; EC 2.7.7.6; hRPC155; POL3A; polymerase (RNA) III (DNA directed) polypeptide A, 155kDa; RNA polymerase III 155 kDa subunit; RNA polymerase III subunit C160; RNA polymerase III subunit RPC155-D; RPC1; RPC155RNA polymerase III subunit C1
Molecular Weight
Mass (kDA):
155.641 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q22.3 |
| Sequence: | 10; NC_000010.11 (77975149..78029515, complement) |
Tissue Specificity
Expressed in the brain, in the cortex and the white matter (at protein level).
Subcellular Localizations
Nucleus.
Diseases
- Hypogonadotropic Hypogonadism
- Hypodontia
- Hypogonadism
- Leukodystrophy
- Ataxia
- Leukoencephalopathies
- Atrophy
- Somatotropin Deficiency
- Cerebellar Diseases
- Neurodegenerative Disorders
Pathways
- Tooth Eruption
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/POLR3A
bosterbio.com/bosterbio-gene-info-cards/POLR3A
References
PMID: 9331371 by Sepehri S., et al. The largest subunit of human RNA polymerase III is closely related to the largest subunit of yeast and trypanosome RNA polymerase III.
PMID: 12384934 by Kuwana M., et al. Identification of an immunodominant epitope on RNA polymerase III recognized by systemic sclerosis sera: application to enzyme-linked immunosorbent assay.