Periplakin Antibodies

AND PPL ELISA kits, Periplakin Proteins

Many biological assays use antibodies to detect Periplakin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Periplakin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Periplakin antibodies...

We validate the specificity of these antibodies to Periplakin by testing them on tissues known to express PPL positively and negatively. Browse below to find the PPL antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PPL Infographic by Boster Bio

All PPL Products

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Anti-Periplakin/PPL Antibody Picoband®

1 Q&As

Flow Cytometry analysis of U20S cells using anti-Periplakin antibody (A02098-1)

Western blot analysis of Periplakin using anti-Periplakin antibody (A02098-1)

IHC analysis of Periplakin using anti-Periplakin antibody (A02098-1)

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A02098-1
100 μg/vial

Periplakin (PPL) (NM_002705) Human Over-expression Lysate

Human

$960
Cat # LS005493
20 µg, 100 µg

PPL Overview

Facts about Periplakin.

PPL 3D structure. Source: alphafold

Periplakin (PPL)

Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments.

May act as a localization signal in PKB/AKT-mediated signaling. .

Gene Information

Human
Gene Name:	PPL
Uniprot:	O60437
Entrez:	5493

Family

Belongs to:

plakin or cytolinker family

Alternative Names

190 kDa paraneoplastic pemphigus antigen; 195 kDa cornified envelope precursor protein; KIAA0568; MGC134872; periplakin

Molecular Weight

Mass (kDA):
204.747 kDA

Genomic Context


Human

Location:	16p13.3
Sequence:	16; NC_000016.10 (4882507..4937148, complement)

Tissue Specificity

Expressed in stratified squamous epithelia and in some other epithelia.

Subcellular Localizations

Cell junction, desmosome. Cytoplasm, cytoskeleton. Cell membrane. Nucleus. Mitochondrion. Associated with desmosomes and intermediate filaments.

Diseases

Allergy
Lung Diseases
Lung Diseases, Obstructive
Malignant Neoplasms
Penicillin Allergy
Chronic Obstructive Airway Disease
Neoplasms
Lymphoma
Lung Neoplasms
Cardiovascular Diseases
Hypertensive Disease

Polyendocrinopathies, Autoimmune
Paraneoplastic Syndromes
Tissue Adhesions
Diabetes Mellitus
Lung Injury
Inflammation

Interacting Proteins

AHCYL1
AKT1
ALAS1
ANXA9
BTN3A1

RAB3IP
RALBP1
TRAF2
TRIM27
TSC22D4

VIM
ZSCAN1

Pathways

Hypersensitivity
Transport
Localization
Pathogenesis
Secretion
Coagulation
Sensitization
Cell Adhesion
Reflex
Anaphylaxis
Innervation
Muscle Contraction
Inflammatory Response

Cell Migration
Lymphocyte Proliferation
Regeneration
Excretion
Immune Response
Cell Death
Killer Activity

PTMs

Phosphorylation
Oxidation
Cleavage
Acylation
Deacetylation
Amination
Acetylation

Carboxylation
Demethylation
Dephosphorylation
Iodination
Reduction
Glycosylation
Palmitoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPL

References

PMID: 9412476 by Ruhrberg C., et al. Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin.

PMID: 9521878 by Aho S., et al. cDNA cloning, mRNA expression, and chromosomal mapping of human and mouse periplakin genes.