Protein phosphatase 1A (PPM1A)

Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, leading to their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling.

Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.