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- Table of Contents
PPP3CA Antibodies
AND PPP3CA ELISA kits, PPP3CA Proteins
Many biological assays use antibodies to detect PPP3CA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PPP3CA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PPP3CA antibodies...
Designing a Western blot for PPP3CA? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PPP3CA Western Blot GuidePPP3CA Infographic by Boster Bio
All PPP3CA Products
Product
Figures
Specificity
Applications
Price
Anti-PPP3CA Antibody Picoband®
1 Citations
Human, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A03026-3
100 µg/vial
Cat # A03026-3
100 µg/vial
Anti-Calcineurin A Rabbit Monoclonal Antibody
2 Citations
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # M03026
100 μl
Cat # M03026
100 μl
PPP3CA Overview
Facts about Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform.
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (PPP3CA)
Calcium-dependent, calmodulin-stimulated protein phosphatase that plays a vital role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:15671020, PubMed:18838687, PubMed:19154138, PubMed:23468591). Many of the substrates contain a PxIxIT motif or a LxVP motif (PubMed:17498738, PubMed:17502104, PubMed:23468591, PubMed:27974827, PubMed:22343722).
In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020). In response to increased Ca(2+) levels after mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation into the mitochondrion (PubMed:18838687).
Gene Information
| Human | |
|---|---|
| Gene Name: | PPP3CA |
| Uniprot: | Q08209 |
| Entrez: | 5530 |
Family
| Belongs to: |
|---|
| PPP phosphatase family |
Alternative Names
calcineurin A alpha; Calcineurin A; Calmodulin-dependent calcineurin A subunit alpha isoform; CALN; CALNA; CALNAcatalytic subunit, alpha isoform; CAM-PRP catalytic subunit; CNA; CNA1; CNA1CALNA1; EC 3.1.3.16; PP2B; PP3CA; PPP2B; PPP2BCCN1; PPP3CA; protein phosphatase 2B, catalytic subunit, alpha isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform(calcineurin A alpha); protein phosphatase 3, catalytic subunit, alpha isozyme; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Molecular Weight
Mass (kDA):
58.688 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q24 |
| Sequence: | 4; NC_000004.12 (101023418..101348295, complement) |
Subcellular Localizations
Cytoplasm. Cell membrane; Peripheral membrane protein. Cell membrane, sarcolemma. Cytoplasm, myofibril, sarcomere, Z line. Cell projection, dendritic spine. Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle (By similarity). Recruited to the cell membrane by scaffold protein AKAP5 following L-type Ca(2+)-channel activation (PubMed:22343722).
Diseases
- Malignant Neoplasms
- Neoplasms
- Alzheimer's Disease
- Carcinoma, Transitional Cell
- Reperfusion Injury
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Thymoma
- Cardiac Hypertrophy
- Bone Neoplasms
- Premature Aging Syndrome
- Malignant Neoplasm Of Lung
- Malignant Neoplasm Of Urinary Bladder
Interacting Proteins
- AKAP5
- Cacng8
- GRB2
- NFATC1
- NFATC2
- PPP3R1
- USP14
- UTRN
Pathways
- Cell Proliferation
- Protein Phosphorylation
- Transport
- Hyperphosphorylation
- Skeletal Muscle Adaptation
- Cell Migration
- Aging
- Oxidative Phosphorylation
- Muscle Adaptation
- Biosynthetic Process
- Localization
- Spermatogenesis
- Cell Death
PTMs
- Phosphorylation
Research Areas
- Adaptive Immunity
- Immunology
- Protein Phosphatase
- Wnt Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPP3CA
bosterbio.com/bosterbio-gene-info-cards/PPP3CA
References
PMID: 8392375 by Muramatsu T., et al. Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha).
PMID: 20590401 by Chiocco M.J., et al. Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease.
2 Publications of Boster PPP3CA Antibodies & ELISA Kits
- PubMed ID: 10.1002/jcp.27791, Ranolazine prevents pressure overload‐induced cardiac hypertrophy and heart fa...
- PubMed ID: 25587324, Buckwheat Rutin Inhibits AngII-induced Cardiomyocyte Hypertrophy via Blockade of...
*More publications can be found for each product on its corresponding product page