PRCP Antibodies

AND PRCP ELISA kits, PRCP Proteins

Many biological assays use antibodies to detect PRCP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PRCP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PRCP antibodies...

We validate the specificity of these antibodies to PRCP by testing them on tissues known to express PRCP positively and negatively. Browse below to find the PRCP antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for PRCP? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the PRCP IHC Guide

PRCP Infographic by Boster Bio

All PRCP Products

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Product

Figures

Specificity

Applications

Price

Anti-PRCP Antibody

1 Citations

Immunohistochemical analysis of paraffin-embedded human Squamous cell carcinoma of lung

Human, Mouse

IF, IHC, WB

$380
Cat # A04829-1
100ul

PRCP (NM_005040) Human Over-expression Lysate

PRCP Human Over-expression Lysates NM_005040

Human

$628
Cat # LS005547
20 µg, 100 µg

Human recombinant PRCP protein

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain

Enzyme Activity, SDS-PAGE

$293
Cat # PROTP42785
Starting from 10ug

PRCP Overview

Facts about Lysosomal Pro-X carboxypeptidase.

PRCP 3D structure. Source: alphafold

Lysosomal Pro-X carboxypeptidase (PRCP)

Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.

Gene Information

Human
Gene Name:	PRCP
Uniprot:	P42785
Entrez:	5547

Family

Belongs to:

peptidase S28 family

Alternative Names

Angiotensinase C; EC 3.4.16.2; HUMPCP; Lysosomal carboxypeptidase C; lysosomal Pro-X carboxypeptidase; PCPMGC2202; PRCP; Proline carboxypeptidase; prolylcarboxypeptidase (angiotensinase C); prolylcarboxypeptidase isoform 1 preproprotein; Prolylcarboxypeptidase

Molecular Weight

Mass (kDA):
55.8 kDA

Genomic Context


Human

Location:	11q14.1
Sequence:	11; NC_000011.10 (82822936..82901740, complement)

Tissue Specificity

Highest levels in placenta, lung and liver. Also present in heart, brain, pancreas and kidney.

Subcellular Localizations

Lysosome.

Diseases

Obesity
Hypertensive Disease
Tumor Angiogenesis
Inflammation
Thrombosis
Neoplasm Metastasis
Carcinoma
Malignant Neoplasms
Neoplasms
Mammary Neoplasms
Ductal Carcinoma
Pre-eclampsia
Cerebrovascular Accident

Cell Invasion
Vascular Diseases
Carotid Artery Thrombosis
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
Coronary Heart Disease
Malignant Neoplasm Of Breast
Hypoxia

Interacting Proteins

GPR37L1

Pathways

Angiogenesis
Proteolysis
Pathogenesis
Receptor-mediated Endocytosis
Cell Proliferation
Cell Migration
Peptide Hormone Processing
Gluconeogenesis
Endocytosis
Localization

Inflammatory Response
Glucose Homeostasis
Reverse Transcription
Cell Growth
Autophagy

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRCP

References

PMID: 8344943 by Tan F., et al. Sequencing and cloning of human prolylcarboxypeptidase (angiotensinase C). Similarity to both serine carboxypeptidase and prolylendopeptidase families.

PMID: 28321 by Odya C.E., et al. Purification and properties of prolylcarboxypeptidase (angiotensinase C) from human kidney.

1 Publications of Boster PRCP Antibodies & ELISA Kits

PubMed ID: 10.1111/j.1440-1681.2008.05079.x, INVOLVEMENT OF PROLYLCARBOXYPEPTIDASE IN THE EFFECT OF RUTAECARPINE ON THE REGRE...

*More publications can be found for each product on its corresponding product page