PREX1 Antibodies

AND PREX1 ELISA kits, PREX1 Proteins

Many biological assays use antibodies to detect PREX1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PREX1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PREX1 antibodies...

We validate the specificity of these antibodies to PREX1 by testing them on tissues known to express PREX1 positively and negatively. Browse below to find the PREX1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for PREX1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the PREX1 IHC Guide

PREX1 Infographic by Boster Bio

All PREX1 Products

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Specificity

Applications

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Anti-PREX1 Antibody Picoband®

Western blot analysis of PREX1 using anti-PREX1 antibody (A03098-2)

Flow Cytometry analysis of MCF-7 cells using anti-PREX1 antibody (A03098-2)

Human

ELISA, Flow Cytometry, WB

$370
Cat # A03098-2
100 µg/vial

Anti-PREX1 Antibody (C-term)

PREX1 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane)

Human

Flow Cytometry, IHC-P, WB

$299
Cat # A03098-1
80 µl

PREX1 Overview

Facts about Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein.

PREX1 3D structure. Source: alphafold

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (PREX1)

Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its action is activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein.

May function downstream of heterotrimeric G proteins in neutrophils. .

Gene Information

Human
Gene Name:	PREX1
Uniprot:	Q8TCU6
Entrez:	57580

Family

Belongs to:

No superfamily

Alternative Names

KIAA1415; phosphatidylinositol 34,5-trisphosphate-dependent Rac exchanger 1 protein; phosphatidylinositol-34,5-trisphosphate-dependent Rac exchange factor 1; PRex1; P-Rex1; ptdIns(34,5)-dependent Rac exchanger 1

Molecular Weight

Mass (kDA):
186.203 kDA

Genomic Context


Human

Location:	20q13.13
Sequence:	20; NC_000020.11 (48624252..48827999, complement)

Subcellular Localizations

Cytoplasm, cytosol. Cell membrane. Mainly cytosolic. Some amount is apparently associated to the plasma membrane.

Diseases

Malignant Neoplasms
Neoplasms
Neoplasm Metastasis
Neoplasm Invasiveness
Cell Invasion
Malignant Neoplasm Of Breast
Tumor Angiogenesis
Mammary Neoplasms
Diabetes Mellitus
Diabetes Mellitus, Non-insulin-dependent
Prostatic Neoplasms
Metastatic Prostate Cancer

Malignant Neoplasm Of Prostate
Kidney Failure, Chronic
Tissue Adhesions
Autoimmunity
Diabetic Nephropathy
Metastatic Malignant Neoplasm To The Lymph Node
Melanoma

Interacting Proteins

Akt1
MTOR
RICTOR
RPTOR

Pathways

Cell Migration
Chemotaxis
Cell Motility
Localization
Cell Growth
Angiogenesis
Secretion
Cell Adhesion
Gastrulation
Neutrophil Chemotaxis
Mitosis
Macrophage Chemotaxis
Dna Methylation

Platelet Activation
Platelet Aggregation
Methylation
Endothelial Cell Migration
Dna Replication
System Development
Leukocyte Chemotaxis

PTMs

Phosphorylation
Dephosphorylation
Carboxylation

Farnesylation
Acetylation
Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PREX1

References

PMID: 11955434 by Welch H.C.E., et al. P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine- nucleotide exchange factor for Rac.