- Table of Contents
Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to activate BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA from the nucleus, inducing the phosphorylation of p53/TP53.
|protein kinase superfamily|
|Sequence:||3; NC_000003.12 (53161209..53192717)|
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Cell membrane; Peripheral membrane protein.
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