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- Table of Contents
PRMT8 Antibodies
AND PRMT8 ELISA kits, PRMT8 Proteins
Many biological assays use antibodies to detect PRMT8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PRMT8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PRMT8 antibodies...
Designing a Western blot for PRMT8? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PRMT8 Western Blot GuideDesigning an IHC experiment for PRMT8? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PRMT8 IHC GuidePRMT8 Infographic by Boster Bio
All PRMT8 Products
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Specificity
Applications
Price
PRMT8 Overview
Facts about Protein arginine N-methyltransferase 8.
Protein arginine N-methyltransferase 8 (PRMT8)
S-adenosyl-L-methionine-dependent and membrane- associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) in proteins such as NIFK, myelin basic protein, histone H4, H2A and H2A/H2B dimer (PubMed:16051612, PubMed:17925405, PubMed:26876602, PubMed:26529540). Willing to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it interacts with completely methylated EWS (PubMed:18320585).
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Gene Information
| Human | |
|---|---|
| Gene Name: | PRMT8 |
| Uniprot: | Q9NR22 |
| Entrez: | 56341 |
Family
| Belongs to: |
|---|
| class I-like SAM-binding methyltransferase superfamily |
Alternative Names
EC 2.1.1; EC 2.1.1.-; EC 2.1.1.77; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4; HMT1 hnRNP methyltransferase-like 3 (S. cerevisiae); HMT1 hnRNP methyltransferase-like 3; HMT1 hnRNP methyltransferase-like 4 (S. cerevisiae); HMT1 hnRNP methyltransferase-like 4; HRMT1L3; HRMT1L4; protein arginine methyltransferase 8; protein arginine N-methyltransferase 4; protein arginine N-methyltransferase 8
Molecular Weight
Mass (kDA):
45.291 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12p13.32 |
| Sequence: | 12; NC_000012.12 (3381349..3593973) |
Tissue Specificity
Brain-specific.
Subcellular Localizations
Cell membrane; Lipid-anchor; Cytoplasmic side.
Diseases
- Sarcoma
- Ewings Sarcoma-primitive Neuroectodermal Tumor (pnet)
- Virus Diseases
- Nervousness
- Bone Neoplasms
- Fish Diseases
- Rhabdoviridae Infections
Interacting Proteins
- PRMT1
- SYNCRIP
Pathways
- Methylation
- Transport
- Aging
- Proteolysis
- Immune Response
- Dna Methylation
- Dna Repair
- Response To Virus
- Localization
- Mrna Splicing
PTMs
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRMT8
bosterbio.com/bosterbio-gene-info-cards/PRMT8
References
PMID: 16051612 by Lee J., et al. PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family.
PMID: 17925405 by Sayegh J., et al. Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain.