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- Table of Contents
PSMB5 Antibodies
AND PSMB5 ELISA kits, PSMB5 Proteins
Many biological assays use antibodies to detect PSMB5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PSMB5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PSMB5 antibodies...
Designing a Western blot for PSMB5? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PSMB5 Western Blot GuideDesigning an IHC experiment for PSMB5? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PSMB5 IHC GuidePSMB5 Infographic by Boster Bio
All PSMB5 Products
Product
Figures
Specificity
Applications
Price
Anti-PSMB5/MB1 Antibody Picoband®
2 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03418-1
100 μg/vial
Cat # A03418-1
100 μg/vial
PSMB5 Overview
Facts about Proteasome subunit beta type-5.
Proteasome subunit beta type-5 (PSMB5)
Component of the 20S core proteasome complex involved in the proteolytic degradation of the majority of intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles.
Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays an integral role in the maintenance of protein homeostasis by eliminating misfolded or damaged proteins that could impair cellular functions, and by eliminating proteins whose functions are no longer required.
Gene Information
| Human | |
|---|---|
| Gene Name: | PSMB5 |
| Uniprot: | P28074 |
| Entrez: | 5693 |
Family
| Belongs to: |
|---|
| peptidase T1B family |
Alternative Names
LMPXproteasome beta 5 subunit; Macropain epsilon chain; MB1EC 3.4.25.1; Multicatalytic endopeptidase complex epsilon chain; proteasome (prosome, macropain) subunit, beta type, 5; proteasome catalytic subunit 3; Proteasome chain 6; Proteasome epsilon chain; proteasome subunit beta type-5; Proteasome subunit MB1; Proteasome subunit X; proteasome subunit, beta type, 5; PSX large multifunctional protease X; XMGC104214
Molecular Weight
Mass (kDA):
28.48 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q11.2 |
| Sequence: | 14; NC_000014.9 (23025851..23035220, complement) |
Subcellular Localizations
Cytoplasm. Nucleus.
Diseases
- Malignant Neoplasms
- Multiple Myeloma
- Neoplasms
- Neuroblastoma
- Carcinoma
- Malignant Neoplasm Of Breast
- Pituitary Diseases
- Mammary Neoplasms
- Glaucoma
- Arthritis
- Hypokinesia
- Nerve Degeneration
- T Lymphoblastic Leukemia/lymphoma
Interacting Proteins
- POMP
- PSMB1
- PSMB3
- PSMB7
Pathways
- Cell Death
- Transport
- Cell Cycle
- Cell Proliferation
- Senescence
- Drug Resistance
- Autophagy
- Immune Response
- Proteolysis
- Spermatogenesis
- Cell Cycle Arrest
- Reverse Transcription
- Gene Silencing
PTMs
- Phosphorylation
- Ubiquitination
Research Areas
- Core ESC-Like Genes
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PSMB5
bosterbio.com/bosterbio-gene-info-cards/PSMB5
References
PMID: 8753855 by Abdulla S., et al. Divergent intron arrangement in the MB1/LMP7 proteasome gene pair.
PMID: 8066462 by Akiyama K.-Y., et al. cDNA cloning and interferon gamma down-regulation of proteasomal subunits X and Y.