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- Table of Contents
Focal adhesion kinase 1 Antibodies
AND PTK2 ELISA kits, Focal adhesion kinase 1 Proteins
Many biological assays use antibodies to detect Focal adhesion kinase 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Focal adhesion kinase 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Focal adhesion kinase 1 antibodies...
Designing a Western blot for Focal adhesion kinase 1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PTK2 Western Blot GuidePTK2 Infographic by Boster Bio
All PTK2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00151
100 μl
Cat # M00151
100 μl
Human, Mouse, Rat
IF, ICC, WB
$370
Cat # P00151
100 μl
Cat # P00151
100 μl
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01066-1
100 μg/vial
Cat # A01066-1
100 μg/vial
Human, Mouse
WB
$370
Cat # M00151Y576Y577
100 µl/vial
Cat # M00151Y576Y577
100 µl/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00151-2
20μL, 40μL, 100μL, 200μL
Cat # M00151-2
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA
$540
Cat # EKC2549
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2549
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2408
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2408
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2407
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2407
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2406
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2406
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2068
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2068
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2031
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2031
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1207
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1207
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2380
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2380
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2379
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2379
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC1998
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1998
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC1997
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1997
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2493
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2493
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2600
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2600
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1490
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1490
1 kit, containing one 96-well plate and all necessary reagents
PTK2 Overview
Facts about Focal adhesion kinase 1.
Focal adhesion kinase 1 (PTK2)
Non-receptor protein-tyrosine kinase which plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Regulates axon development and neuronal cell migration, axon branching and synapse formation; necessary for normal development of the nervous system.
Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors.
Gene Information
| Human | |
|---|---|
| Gene Name: | PTK2 |
| Uniprot: | Q05397 |
| Entrez: | 5747 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.10; FADK 1; FADK1; FADKFAK-related non-kinase polypeptide; FAK; FAK1FRNK; FAKEC 2.7.10.2; focal adhesion kinase 1; pp125FAK; Protein-tyrosine kinase 2; PTK2 protein tyrosine kinase 2; PTK2
Molecular Weight
Mass (kDA):
119.233 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q24.3 |
| Sequence: | 8; NC_000008.11 (140657900..141002079, complement) |
Tissue Specificity
Detected in B and T-lymphocytes. Isoform 1 and isoform 6 are detected in lung fibroblasts (at protein level). Ubiquitous.
Subcellular Localizations
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Constituent of focal adhesions. Detected at microtubules.
Diseases
- Tissue Adhesions
- Neoplasms
- Malignant Neoplasms
- Cell Invasion
- Neoplasm Metastasis
- Carcinoma
- Neoplasm Invasiveness
- Tumor Angiogenesis
- Malignant Neoplasm Of Breast
- Malignant Paraganglionic Neoplasm
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Lung Neoplasms
Interacting Proteins
- BCAR1
- CRK
- CRKL
- EGFR
- EPHA2
- ERBB2
- FLT1
- GRB7
- ITGB4
- PIK3R3
Pathways
- Cell Adhesion
- Cell Migration
- Cell Proliferation
- Cell Motility
- Localization
- Angiogenesis
- Cell Growth
- Cell Cycle
- Secretion
- Cell Death
- Wound Healing
- Anoikis
- Pathogenesis
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
- Ribosylation
- Ubiquitination
- Amidation
- Methylation
- Glycosylation
- Oxidation
- Geranylgeranylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTK2
bosterbio.com/bosterbio-gene-info-cards/PTK2
References
PMID: 7692878 by Whitney G.S., et al. Human T and B lymphocytes express a structurally conserved focal adhesion kinase, pp125FAK.
PMID: 8422239 by Andre E., et al. Expression of an N-terminally truncated form of human focal adhesion kinase in brain.
6 Publications of Boster Focal adhesion kinase 1 Antibodies & ELISA Kits
- PubMed ID: 10.3389/fphys.2018.01343, Knee Extensors Muscle Plasticity Over a 5-Years Rehabilitation Process After Ope...
- PubMed ID: 10.1016/j.yexmp.2019.03.006, Focal adhesion kinase coordinates costamere-related JNK signaling with muscle fi...
- PubMed ID: 31773683, Effect of celecoxib on protein expression of FAK and Cx43 in DMBA induced rat to...
- PubMed ID: 30337877, Knee extensors muscle plasticity over a 5-years rehabilitation process after ope...
- PubMed ID: 25621028, Su Gq, Zhang Fx, Mao Hh, Liu Xw, Zheng Ys, Zhang Sy, Su Jj. Oncol Lett. 2015 Feb...
- PubMed ID: 24348806, Cao T, Xing Y, Yang Y, Mei H. Exp Ther Med. 2014 Jan;7(1):280-286. Epub 2013 Nov...
*More publications can be found for each product on its corresponding product page