Focal adhesion kinase 1 (PTK2)

Non-receptor protein-tyrosine kinase which plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Regulates axon development and neuronal cell migration, axon branching and synapse formation; necessary for normal development of the nervous system.

Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors.