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PTPRZ1 Antibodies
AND PTPRZ1 ELISA kits, PTPRZ1 Proteins
Many biological assays use antibodies to detect PTPRZ1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PTPRZ1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PTPRZ1 antibodies...
Designing a Western blot for PTPRZ1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PTPRZ1 Western Blot GuideDesigning an IHC experiment for PTPRZ1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PTPRZ1 IHC GuidePTPRZ1 Infographic by Boster Bio
All PTPRZ1 Products
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PTPRZ1 Overview
Facts about Receptor-type tyrosine-protein phosphatase zeta.
Receptor-type tyrosine-protein phosphatase zeta (PTPRZ1)
Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells to mature, fully myelinating oligodendrocytes.
May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably through the dephosphorylation of proteins which are part of important signaling cascades (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | PTPRZ1 |
| Uniprot: | P23471 |
| Entrez: | 5803 |
Family
| Belongs to: |
|---|
| protein-tyrosine phosphatase family |
Alternative Names
3F8 CSPG ; HPTPZ; phosphacan; protein tyrosine phosphatase, receptor-type, Z polypeptide 1; PTP beta/zeta; PTP18; PTPRZ; PTPRZ1; PTPZ; receptor-type, zeta polypeptide 1; RPTPB; RPTPbeta
Molecular Weight
Mass (kDA):
254.587 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q31.32 |
| Sequence: | 7; NC_000007.14 (121873161..122062036) |
Tissue Specificity
Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain.
Subcellular Localizations
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Secreted. A secreted form is apparently generated by shedding of the extracellular domain.; [Isoform 2]: Secreted.
Diseases
- Nervousness
- Tissue Adhesions
- Neoplasms
- Glioblastoma
- Glioma
- Malignant Neoplasms
- Malignant Paraganglionic Neoplasm
- Posttransfusion Purpura
- Brain Neoplasms
- Astrocytoma
- Lymphoma
- Neuroblastoma
Interacting Proteins
- ALK
- CNTN1
Pathways
- Cell Adhesion
- Localization
- Cell Migration
- Regeneration
- Pathogenesis
- Myelination
- Axon Guidance
- Cell Proliferation
- Glycosylation
- Brain Development
- Cell-cell Adhesion
- System Development
- Nervous System Development
PTMs
- Phosphorylation
- Dephosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTPRZ1
bosterbio.com/bosterbio-gene-info-cards/PTPRZ1
References
PMID: 1323835 by Krueger N.X., et al. A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases.
PMID: 8387522 by Levy J.B., et al. The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system.