Peroxidasin homolog Antibodies

Peroxidasin homolog (PXDN)

Displays low peroxidase activity and is very likely to take part in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular matrix formation.

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Gene Information

Human
Gene Name:	PXDN
Uniprot:	Q92626
Entrez:	7837

Family

Belongs to:
peroxidase family

Alternative Names

peroxidasin homolog (Drosophila)

Molecular Weight

Mass (kDA):
165.275 kDA

Genomic Context

Human
Location:	2p25.3
Sequence:	2; NC_000002.12 (1631887..1744852, complement)

Tissue Specificity

Expressed at higher levels in heart, lung, ovary, spleen, intestine and placenta, and at lower levels in liver, colon, pancreas, kidney, thymus, skeletal muscle and prostate. Expressed in tumors such as melanoma, breast cancer, ovarian cancer and glioblastoma. A shorter form probably lacking the signal sequence is found in testis and in EB1 cells undergoing p53/TP53-dependent apoptosis.

Subcellular Localizations

Secreted, extracellular space, extracellular matrix. Enriched in the peritubular space of fibrotic kidneys.

Diseases

• Neoplasms
• Neoplasm Metastasis
• Chromosomal Duplication
• Schizophrenia
• Tissue Adhesions
• Melanoma
• Glioma
• Endometrial Polyp
• Irido-corneal Dysgenesis
• Leukemia, Myelocytic, Acute
• Metastatic Malignant Neoplasm To Brain
• Tumor Angiogenesis

• Endometritis
• Malignant Neoplasms
• Flushing
• Puerperal Disorders
• Myeloid Leukemia
• Loss Of Chromosome 5q

Pathways

• Cell Adhesion
• Transport
• Glycosylation
• Localization
• Methylation
• Swimming
• Cell Cycle
• Cell Motility
• Amino Acid Transport

• Regulation Of Cell Motility
• Cell Growth
• Angiogenesis
• Protein Stabilization

PTMs

• Phosphorylation
• Demethylation

• Glycosylation
• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PXDN

Best Uses Of The PXDN Marker

PXDN markers are highly relevant in the study human inflammatorybowel disease. The protein is a receptor to a cytokine named PXD2. These markers can help scientists understand the process of inflammatory bowel diseases. Boster bio has this marker. In this article, we'll discuss the uses of this marker, how they work, and how these antibodies can help researchers.

Boster offers high-affinity primary antibodies

Boster Bio has high-affinity prima antibodies. Boster Bio is home to over 16,000 antibodies. Many have been validated by IHC, FC, WB, FC and ELISA. They also sell rabbit monoclonal antibodies. They also offer a complimentary secondary antibody with every primary antibody.

Flow Cytometry has many applications in biology. It can be used for everything from disease detection to tumor research. The sample is broken down into particles to allow for analysis. Boster offers both monoclonal and polyclonal antibodies that are high in affinity. Boster's high affinity primary antibodies have been cited numerous times and have remained in constant supply for over 25-years. They are also available as custom services.

Secondary antibodies are often used as labels for specimens. A primary-secondary antigen system allows you more questions to be asked when it is paired with specimens. This method provides more robust and contextual data. This method can also detect specific molecules or cell types. Boster Bio provides high-affinity prima antibodies. You can find them at Boster Bio or any other reputable supplier.

FAQs

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Frequently Asked Questions

The PXDN Marker may function as a signaling protein. It contains four Ig-like C2-type domains, an N-terminal leucine-rich repeat (LRR) domain, and four immunoglobulin domains, as well as a von Willebrand factor C module. These domains, which are characteristic for ECM protein domains, are well-known for participating in protein–protein interactions. The unique design of the PXDN marker is due to its hybrid structure. It combines an enzymatically-functional peroxidase domain and motifs common in extracellular matrix-associated protein.

The PXDN Marker is an important cancer-specific protein. It is highly expressed in many types of cancer. These include breast cancer, prostate cancer, brain tumors, endometrial cancer, ovarian cancer, and colon cancer. Its expression is strongly linked to poor patient outcomes. To determine whether the PXDN marker is accurate in detecting melanoma cells, additional research is needed.