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- Table of Contents
Pdcd4 Antibodies
AND Pdcd4 ELISA kits, Pdcd4 Proteins
Many biological assays use antibodies to detect Pdcd4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Pdcd4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Pdcd4 antibodies...
Designing a Western blot for Pdcd4? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PDCD4 Western Blot GuideDesigning an IHC experiment for Pdcd4? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PDCD4 IHC GuidePdcd4 Infographic by Boster Bio
All Pdcd4 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01105
100 μl
Cat # M01105
100 μl
Human, Mouse, Rat
ELISA
$540
Cat # EKC2326
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2326
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2325
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2325
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1445
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1445
1 kit, containing one 96-well plate and all necessary reagents
Pdcd4 Overview
Facts about Programmed cell death protein 4.
Programmed cell death protein 4 (Pdcd4)
May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A.
Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Pdcd4 |
| Uniprot: | Q61823 |
| Entrez: | 18569 |
Family
| Belongs to: |
|---|
| PDCD4 family |
Alternative Names
H731; H731nuclear antigen H731; MGC33046; MGC33047; Neoplastic transformation inhibitor protein; Nuclear antigen H731-like; PDCD4; programmed cell death 4 (neoplastic transformation inhibitor); programmed cell death protein 4; Protein 197/15a
Molecular Weight
Mass (kDA):
51.702 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 19 D2|19 48.73 cM |
| Sequence: | 19; |
Tissue Specificity
Expressed ubiquitously. Highyly expressed in thymus and liver. Moderately expressed in brain, kidney and spleen; weakly in lung and heart. Expression is up- or down- regulated in response to apoptosis inducers. Regulated by many programmed cell death-inducing stimuli.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Neoplasm Metastasis
- Cell Invasion
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Malignant Paraganglionic Neoplasm
- Neoplasm Invasiveness
- Adenocarcinoma
- Carcinogenesis
- Tumor Progression
Pathways
- Cell Death
- Programmed Cell Death
- Translation
- Cell Proliferation
- Cell Cycle
- Cell Growth
- Pathogenesis
- Cell Migration
- Localization
- Oncogenesis
- Cell Differentiation
- Reverse Transcription
- Angiogenesis
PTMs
- Phosphorylation
- Cleavage
- Methylation
- Demethylation
- Biotinylation
Research Areas
- Apoptosis
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Pdcd4
bosterbio.com/bosterbio-gene-info-cards/Pdcd4
References
PMID: 8543179 by Shibahara K., et al. Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death.
PMID: 8912629 by Onishi Y., et al. Molecular cloning of the genes suppressed in RVC lymphoma cells by topoisomerase inhibitors.