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- Table of Contents
Profilin-1 Antibodies
AND PFN1 ELISA kits, Profilin-1 Proteins
Many biological assays use antibodies to detect Profilin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Profilin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Profilin-1 antibodies...
Designing a Western blot for Profilin-1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PFN1 Western Blot GuideDesigning an IHC experiment for Profilin-1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PFN1 IHC GuidePFN1 Infographic by Boster Bio
All PFN1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9313
100 μg/vial
Cat # PB9313
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M01480
100 μl
Cat # M01480
100 μl
PFN1 Overview
Facts about Profilin-1.
Profilin-1 (PFN1)
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.
By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
Gene Information
| Human | |
|---|---|
| Gene Name: | PFN1 |
| Uniprot: | P07737 |
| Entrez: | 5216 |
Family
| Belongs to: |
|---|
| profilin family |
Alternative Names
PFN1; PROF1; Profilin 1; Profilin I; profilin-1
Molecular Weight
Mass (kDA):
15.054 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17p13.2 |
| Sequence: | 17; NC_000017.11 (4945652..4948530, complement) |
Tissue Specificity
Expressed in epididymis (at protein level).
Subcellular Localizations
Cytoplasm, cytoskeleton.
Diseases
- Tissue Adhesions
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Carcinoma
- Protrusion
- Wiskott-aldrich Syndrome
- Adenocarcinoma
- Inflammation
- Leukemia
- Liver Carcinoma
Interacting Proteins
- ACTB
- WASF1
- Wasl
Pathways
- Localization
- Cell Motility
- Cell Adhesion
- Cell Growth
- Cell Migration
- Cytokinesis
- Cell Proliferation
- Transport
- Pathogenesis
- Exocytosis
- Cell-cell Adhesion
- Cell Cycle
- Endocytosis
PTMs
- Phosphorylation
- Cleavage
- Dephosphorylation
- Methylation
Research Areas
- Cancer
- Cell Biology
- Cellular Markers
- Neuronal Cell Markers
- Neuroscience
- Signal Transduction
- Stem Cell Markers
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PFN1
bosterbio.com/bosterbio-gene-info-cards/PFN1
References
PMID: 3356709 by Kwiatkowski D.J., et al. Human profilin. Molecular cloning, sequence comparison, and chromosomal analysis.
PMID: 20736409 by Li J., et al. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins.