This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Pld6 Antibodies
AND Pld6 ELISA kits, Pld6 Proteins
Many biological assays use antibodies to detect Pld6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Pld6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Pld6 antibodies...
Designing an IHC experiment for Pld6? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PLD6 IHC GuidePld6 Infographic by Boster Bio
All Pld6 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A10904-1
100 µg/vial
Cat # A10904-1
100 µg/vial
Pld6 Overview
Facts about Mitochondrial cardiolipin hydrolase.
Mitochondrial cardiolipin hydrolase (Pld6)
Endonuclease that plays a critical role in PIWI- interacting RNA (piRNA) biogenesis during spermatogenesis. PiRNAs provide essential protection against the activity of mobile genetic elements.
PiRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (PubMed:23064227, PubMed:23064230). Has been proposed to serve as a cardiolipin hydrolase to create phosphatidic acid in mitochondrial surface (PubMed:21397847, PubMed:21397848).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Pld6 |
| Uniprot: | Q5SWZ9 |
| Entrez: | 194908 |
Family
| Belongs to: |
|---|
| phospholipase D family |
Alternative Names
Choline phosphatase 6; EC 3.1.4.-; Mitochondrial phospholipase; MitoPLD; Phosphatidylcholine-hydrolyzing phospholipase D6; phospholipase D family, member 6; Phospholipase D6; PLD 6; Protein zucchini homolog
Molecular Weight
Mass (kDA):
25.041 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 11|11 B1.3 |
| Sequence: | 11; |
Tissue Specificity
Predominantly expressed in testis (at protein level). Also expressed at high levels in growing ovary.
Diseases
- Down Syndrome
- Trisomy
Pathways
- Methylation
- Dna Methylation
PTMs
- Demethylation
Research Areas
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Pld6
bosterbio.com/bosterbio-gene-info-cards/Pld6
References
PMID: 21397847 by Watanabe T., et al. MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline.
PMID: 21397848 by Huang H., et al. piRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signaling.