PLXDC1 Antibodies

AND PLXDC1 ELISA kits, PLXDC1 Proteins

Many biological assays use antibodies to detect PLXDC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PLXDC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PLXDC1 antibodies...

We validate the specificity of these antibodies to PLXDC1 by testing them on tissues known to express PLXDC1 positively and negatively. Browse below to find the PLXDC1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for PLXDC1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the PLXDC1 IHC Guide

PLXDC1 Infographic by Boster Bio

All PLXDC1 Products

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Figures

Specificity

Applications

Price

Anti-TEM7 PLXDC1 Antibody

Western blot analysis of TEM7 in human liver tissue lysate with TEM7 antibody at (A) 0

Immunohistochemistry of TEM7 in mouse liver tissue with TEM7 antibody at 2

Immunofluorescence of TEM7 in mouse liver tissue with TEM7 antibody at 20 μg/mL

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$481
Cat # A08584-1
0.1 mg

TEM7 (PLXDC1) (NM_020405) Human Over-expression Lysate

Human

$628
Cat # LS057125
20 µg, 100 µg

PLXDC1 Overview

Facts about Plexin domain-containing protein 1.

PLXDC1 3D structure. Source: alphafold

Plexin domain-containing protein 1 (PLXDC1)

Plays a critical role in endothelial cell capillary morphogenesis. .

Gene Information

Human
Gene Name:	PLXDC1
Uniprot:	Q8IUK5
Entrez:	57125

Family

Belongs to:

plexin family

Alternative Names

FLJ45632; plexin domain containing 1,2410003I07Rik; plexin domain-containing protein 1; PLXDC1; TEM3; TEM3FLJ36270; TEM7; TEM7DKFZp686F0937; Tumor endothelial marker 3; Tumor endothelial marker 7

Molecular Weight

Mass (kDA):
55.76 kDA

Genomic Context


Human

Location:	17q12
Sequence:	17; NC_000017.11 (39063313..39151637, complement)

Tissue Specificity

Detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue. Expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy.

Subcellular Localizations

[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.; [Isoform 4]: Cytoplasm.

Diseases

Neoplasms
Malignant Neoplasms
Sarcoma
Pathologic Neovascularization
Neoplasm Metastasis
Bone Neoplasms
Carcinoma
Osteosarcoma
Epiretinal Membrane
Malignant Neoplasm Of Breast
Endometrial Polyp
Malignant Neoplasm Of Liver

Neoplasm Invasiveness
Tumor Angiogenesis
Sciatic Neuropathy
Hemorrhage
Nervousness
Malignant Neoplasm Of Ovary
Epithelial Ovarian Cancer

Pathways

Regeneration
Cell Proliferation
Phagocytosis
Gene Silencing
Angiogenesis
Endothelial Cell Proliferation

Antibody-dependent Cellular Cytotoxicity

PTMs

Glycoprotein

Research Areas

Angiogenesis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLXDC1

References

PMID: 10947988 by St Croix B., et al. Genes expressed in human tumor endothelium.

PMID: 11559528 by Carson-Walter E.B., et al. Cell surface tumor endothelial markers are conserved in mice and humans.