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RAB10 Antibodies
AND RAB10 ELISA kits, RAB10 Proteins
Many biological assays use antibodies to detect RAB10, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RAB10 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RAB10 antibodies...
Designing a Western blot for RAB10? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RAB10 Western Blot GuideRAB10 Infographic by Boster Bio
All RAB10 Products
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RAB10 Overview
Facts about Ras-related protein Rab-10.
Ras-related protein Rab-10 (RAB10)
The little GTPases Rab are crucial regulators of intracellular membrane trafficking, from the formation of transport vesicles to their combination with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that's able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, motion, tethering and fusion (By similarity).
That Rab is mostly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane.
Gene Information
| Human | |
|---|---|
| Gene Name: | RAB10 |
| Uniprot: | P61026 |
| Entrez: | 10890 |
Family
| Belongs to: |
|---|
| small GTPase superfamily |
Alternative Names
GTP-binding protein RAB10; RAB10, member RAS oncogene family; ras-related GTP-binding protein; ras-related protein Rab-10
Molecular Weight
Mass (kDA):
22.541 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p23.3 |
| Sequence: | 2; NC_000002.12 (26034084..26137454) |
Subcellular Localizations
Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane. Golgi apparatus, trans-Golgi network membrane. Endosome membrane. Recycling endosome membrane. Cytoplasmic vesicle, phagosome membrane. Cytoplasm, cytoskeleton, cilium basal body. Endoplasmic reticulum membrane. Cytoplasm, perinuclear region. Associates with SLC2A4/GLUT4 storage vesicles (PubMed:22908308). Localizes to the base of the cilium when phosphorylated by LRRK2 on Thr-73 (PubMed:20576682, PubMed:30398148). Transiently associates with phagosomes (By similarity). Localizes to the endoplasmic reticulu
Diseases
- Diabetes Mellitus, Non-insulin-dependent
- Diabetes Mellitus
- Insulin Resistance
- Malignant Neoplasms
- Hypopigmentation-immunodeficiency Disease
- Hyperinsulinism
- Lymphohistiocytosis, Hemophagocytic
- Melanoma
- Malignant Tumor Of Colon
- Carcinoma
- Tumor Angiogenesis
- Neoplasms
- Headache
Interacting Proteins
- EMP3
- LRRK2
- OPTN
- RAB39A
Pathways
- Transport
- Localization
- Exocytosis
- Endocytic Recycling
- Secretion
- Rna Interference
- Glucose Transport
- Secretory Pathway
- Phagosome Maturation
- Protein Targeting
- Pigmentation
- Protein Secretion
- Inflammatory Response
PTMs
- Phosphorylation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RAB10
bosterbio.com/bosterbio-gene-info-cards/RAB10
References
PMID: 12450215 by He H., et al. Identification and characterization of nine novel human small GTPases showing variable expressions in liver cancer tissues.
PMID: 16641372 by Babbey C.M., et al. Rab10 regulates membrane transport through early endosomes of polarized Madin-Darby canine kidney cells.